When Lung Cancer Changes Identity: Study Maps the Immune Shift Behind Drug Resistance
A paired genomic and transcriptomic study of 32 patients shows that EGFR-mutant lung adenocarcinoma transforms into an immunosuppressed yet immunologically ...
Tag: drug resistance
Blood Levels of Liver Cancer Drug Lenvatinib Predict Who Responds to Treatment
A multi-omics study of 194 liver cancer patients shows that lenvatinib blood concentrations above 26.5 ng/mL predict treatment response, while ...
Hidden RNA switches reshape cancer proteins and sabotage drug targets
A comprehensive multi-omics study catalogues thousands of cancer-specific isoform switches in melanoma, ovarian cancer, and AML, showing that most disrupt ...
NIH Backs $13.1 Million Effort to Attack Breast Cancer with Engineered Salmonella
A five-year, $13.1 million NIH grant will fund engineered, nontoxic Salmonella designed to deliver radiopharmaceutical therapy, viral payloads, and immune-targeting ...
Hidden Leukemic Stem Cells That Fuel Relapse in FLT3-Mutated AML Finally Exposed
Researchers have functionally characterized CD34/CD123/CD25/CD99-positive leukemic progenitor cells in FLT3-ITD-mutated AML, showing they engraft and reinitiate leukemia in mice and ...
Mapping the Hidden Battlefield: Spatial Atlas Tracks How Lung Tumors Evolve to Outsmart Targeted Drugs
A longitudinal spatial multi-omics study reveals how the tumor microenvironment in EGFR-mutant lung cancer remodels in distinct stages as patients ...
New AI Tool miRDrug Maps the Shared Genes Behind MicroRNAs, Drugs and Resistance
Researchers have developed miRDrug, a machine-learning platform that integrates three biological databases to map the shared genes linking microRNAs, drugs ...
NIH Pioneer Award Backs Scientist Building Cancer Therapies That Evolve Alongside Tumors
NIH has awarded its Director's Pioneer Award to Sylvester Comprehensive Cancer Center virologist Leor Weinberger for developing an evolving oncolytic ...
Hidden DNA Rings and a Rogue Gene Reveal Ovarian Cancer’s Adaptive Defense
A new study links HDAC inhibitor treatment to remodeling of extrachromosomal circular DNA in ovarian cancer and identifies LMO2 as ...
Giant Muscle Gene Titin Emerges as a Driver of Drug-Resistant Childhood Leukemia
A study of 152 Chinese children with acute lymphoblastic leukemia links mutations in the titin gene to prednisone resistance, poor ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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