Bioinformatics pipelines race to outsmart multidrug-resistant tuberculosis
A new review maps how machine learning, molecular docking and subtractive genomics are being combined to explain drug resistance in ...
Tag: drug resistance
RAS Inhibitor Daraxonrasib Redefines Pancreatic Cancer Treatment After FDA Approval
A phase 3 trial of the pan-RAS inhibitor daraxonrasib doubled median overall survival in previously treated metastatic pancreatic cancer, prompting ...
Host-derived peptide shows antiviral activity against herpes simplex virus type 1 in vitro
Scientists engineered an HVEM-derived peptide that blocked about sixty percent of HSV-1 infection in cell tests without toxicity.
Pretomanid resistance found in 4.5% of tuberculosis isolates in China
A study of 335 Mycobacterium tuberculosis isolates in China found a pretomanid 99th percentile MIC of 0.25 mg/L in 7H9 ...
Four Decades of Anticancer Quinazoline Research Mapped in New Bibliometric Study
A new bibliometric and pharmacological review of 423 Scopus-indexed publications maps four decades of anticancer quinazoline research, revealing a 2018 ...
HSP90 Chaperone Isoforms Emerge as Precision Targets in Lung Cancer
A new review maps how the four HSP90 chaperone isoforms play distinct roles in lung cancer progression and drug resistance, ...
Nanomedicine Aims to Sharpen Colorectal Cancer Diagnosis and Treatment
A new open-access review in Cancer Nanotechnology surveys how nanomaterials could improve colorectal cancer diagnosis, targeted therapy, and personalized theranostics.
Small Molecule Strategy Degrades Many Disease Proteins at Once in Cell Models
A new small molecule strategy activates a stress-responsive E3 ligase to degrade multiple disease-causing proteins at once, restoring mitochondrial function ...
CD84 Levels Predict Venetoclax Response in Acute Myeloid Leukemia
High CD84 expression correlates with venetoclax resistance in AML, and targeting the CD84-SESN2 pathway sensitized leukemia cells to the drug ...
Cancer’s rogue DNA: how ecDNA reshapes itself to survive treatment
A new review in Cellular Oncology argues that treatment resistance in cancer often stems from selection and remodeling of pre-existing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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