Giant Muscle Gene Titin Emerges as a Driver of Drug-Resistant Childhood Leukemia
A study of 152 Chinese children with acute lymphoblastic leukemia links mutations in the titin gene to prednisone resistance, poor ...
Tag: drug resistance
Old Cancer Drug Candidate Irosustat Shows Promise Against Drug-Resistant Malaria
Researchers report that the steroid sulfatase inhibitor irosustat and its target molecule cholesterol sulfate inhibit drug-resistant Plasmodium falciparum through a ...
Isoniazid Reborn: Computational Design Yields a Schiff Base Lead That Outperforms a First-Line TB Drug
A virtual library of 30 isoniazid-based Schiff base derivatives was computationally screened, and the top-ranked compound SLB-5 was synthesized and ...
Immunotherapy Breakthroughs and Single-Cell Atlas Studies Reshape Liver Cancer Care in China
A 2023 review from Fudan University documents how Chinese clinical trials and single-cell omics studies are transforming the treatment and ...
MUC1: The Sticky Protein That Turns Guardian of Epithelia Into Engine of Cancer
A sweeping new review maps how the epithelial guardian protein MUC1, and especially its MUC1-C signaling subunit, is hijacked by ...
Lung Cancer Outsmarts KRAS Drugs Through Two Distinct Escape Routes
MIT researchers have found that lung adenocarcinomas can evade KRAS inhibitors either by amplifying the KRAS gene or by transforming ...
How Immunotherapy Turned Deadly Melanoma Into a Treatable Cancer
A new review details how immune checkpoint inhibitors, cell therapies, vaccines and oncolytic viruses have transformed melanoma treatment while highlighting ...
Lifeguard Protein Rewires Stress Genes in Triple-Negative Breast Cancer Cells
Silencing the anti-apoptotic protein Lifeguard in triple-negative breast cancer cells alters intracellular calcium levels and reshapes the expression of endoplasmic ...
New Leukemia Drug Shows Stunning First-Line Results, but Experts Urge Caution on Treatment Order
Phase III success has made pirtobrutinib a first-line candidate for chronic lymphocytic leukemia, but resistance biology and missing reverse-sequence data ...
How a Single Gene Loss Helps Melanoma Outsmart Targeted Drugs
An integrative multi-omics study reveals how loss of the chromatin factor ARID1A rewires receptor and kinase signaling in melanoma, driving ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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