Nanomedicine Aims to Sharpen Colorectal Cancer Diagnosis and Treatment
A new open-access review in Cancer Nanotechnology surveys how nanomaterials could improve colorectal cancer diagnosis, targeted therapy, and personalized theranostics.
Tag: drug resistance
Small Molecule Strategy Degrades Many Disease Proteins at Once in Cell Models
A new small molecule strategy activates a stress-responsive E3 ligase to degrade multiple disease-causing proteins at once, restoring mitochondrial function ...
CD84 Levels Predict Venetoclax Response in Acute Myeloid Leukemia
High CD84 expression correlates with venetoclax resistance in AML, and targeting the CD84-SESN2 pathway sensitized leukemia cells to the drug ...
Cancer’s rogue DNA: how ecDNA reshapes itself to survive treatment
A new review in Cellular Oncology argues that treatment resistance in cancer often stems from selection and remodeling of pre-existing ...
Enzyme Rivalry in Tumors: How Arginine Methyltransferases Cooperate and Compete in Cancer
A new review maps how protein arginine methyltransferases both cooperate and antagonize one another in tumors, arguing that multi-target and ...
Lab-Grown Tumor Organoids With Immune Cells Aim to Predict Immunotherapy Response
A new review examines how patient-derived tumor organoids retaining immune cells could improve preclinical prediction of immunotherapy response while noting ...
Methylated translation factor speeds decoding of rare codons to drive cancer growth
A methylation mark on translation factor eEF1A selectively speeds decoding of rare, wobble-weak codons, boosting KRAS production and driving resistance ...
Starving Ovarian Cancer Cells of Cysteine May Boost Carboplatin Response
Preclinical experiments show that depriving ovarian cancer cells of cyst(e)ine, or blocking its metabolism with drugs, enhances their responsiveness to ...
Lab-Grown Bone Marrow Models Reshape How Myeloma Is Studied
A new review maps how 3D bone marrow models, from spheroids to bioprinted and organ-on-chip systems, are being used to ...
Research report: Multirefractory pediatric advanced systemic mastocytosis and mast cell leukemia with a subsequently detected KIT N822K mutation: a case report
A published case report describes an 8-year-old boy with multirefractory advanced systemic mastocytosis and mast cell leukemia in whom a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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