Tag: drug resistance

Cryo-electron microscopy structures of the Mycobacterium tuberculosis DprE1–DprE2 epimerase complex reveal its tetrameric architecture and the precise binding modes of ...

A sweeping integrated genomics study reveals that chemotherapy-resistant tumors across multiple cancer types share a hyperproliferative, MYC-driven state, identifying the ...

A new review argues that deubiquitinase enzymes within the ubiquitin-proteasome system offer promising therapeutic angles against KRAS-driven cancers that resist ...

A new Cell Research study shows that BCR-ABL1 forms liquid-like phase-separated condensates inside leukemic cells that physically slow tyrosine kinase ...

Researchers have engineered EB-18, a phosphonium-substituted derivative of the classic chemotherapy drug 5-fluorouracil that outperforms 5-FU and standard agents in ...

Two landmark New England Journal of Medicine studies show the pan-RAS inhibitor daraxonrasib nearly doubles survival in previously treated metastatic ...

Researchers report that two compounds from the soil bacterium Streptomyces chrestomyceticus ADP4 inhibit both the CYP51 ergosterol enzyme and exo-beta-1,3-glucanase ...

A new review explains how the contest between BRCA1-BARD1 and the 53BP1 axis at DNA break ends determines whether cells ...

New research shows that the blood lipid protein ApoA2 promotes metastasis and chemotherapy resistance in hepatocellular carcinoma by activating an ...

A new review in Molecular Cancer details how five classes of nanomaterials could breach the blood–brain barrier and dismantle the ...