Apoptosis Gene Patterns Reveal Distinct AML Subgroups and Flag BIK as a Surprising Prognostic Marker
A new study of 90 AML patients shows that apoptosis gene expression patterns define two biologically distinct leukemia subgroups with ...
Tag: drug resistance
Ukraine’s Drug-Resistant Tuberculosis Epidemic Is Driven by a Handful of Dominant Clones
The largest genomic survey of tuberculosis in Ukraine to date shows that drug-resistant disease is overwhelmingly driven by a few ...
New Sequencing Test Shows Strong Accuracy in Spotting Drug-Resistant Tuberculosis
A Ugandan verification study found the Deeplex Myc-TB targeted sequencing assay achieved perfect specificity and strong sensitivity for key tuberculosis ...
ATR Inhibitor Ceralasertib Restores Trifluridine’s Power Against Drug-Resistant Colorectal Cancer
New preclinical research shows that the ATR inhibitor ceralasertib (AZD6738) synergistically restores and amplifies the antitumor activity of trifluridine in ...
Dark DNA’s Long RNAs Emerge as Master Regulators of Colorectal Cancer
A major new review shows that long non-coding RNAs orchestrate the colorectal cancer tumour microenvironment, offering new biomarkers and therapeutic ...
Beyond KRAS G12C: New Drug Wave Targets Once-Undruggable Cancer Driver
A new review maps the fast-moving landscape of next-generation KRAS inhibitors, degraders, and combination strategies now advancing beyond the first ...
Targeting Host RNA-Binding Proteins Could Yield Broad-Spectrum Antivirals
A new review in npj Viruses argues that host RNA-binding proteins, which many unrelated viruses hijack during replication, could serve ...
KIF11 Inhibition Rewires Prostate Cancer Cell Identity to Restore Sensitivity to Antiandrogen Drugs
Low-dose inhibition of the motor protein KIF11 rebuilds enhancer–promoter loops at the androgen receptor locus, restoring drug sensitivity in otherwise ...
Metabolic Weaknesses Exposed in Prostate Cancer That Resists Enzalutamide
Multi-omic profiling of enzalutamide-resistant prostate cancer cells has revealed rewired lipid, glutamine and mitochondrial metabolism that creates druggable vulnerabilities and ...
Cancer Therapy Reshapes Mutation Competition in Healthy Esophageal Tissue
New research shows that cancer therapy selects for preexisting drug-resistant and druggable mutant clones in normal esophageal tissue, reshaping the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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