AI Peptide Drug Models Score High, but a Landmark Audit Reveals a Hidden Reproducibility Crisis
A new systematic review and meta-analysis of 23 studies finds that machine learning models for peptide–target interaction prediction achieve strong ...
Tag: drug discovery
Computational Screening Points to Two Quinoline Candidates Against Tuberculosis and Resistant Infections
Computational screening of four halogenated quinoline derivatives identifies QNL1 and QNL3 as promising oral drug candidates against tuberculosis, E. coli, ...
Tuberculosis Bacteria’s Secreted Proteins Emerge as New Drug Targets
A new review maps the secreted virulence proteins of Mycobacterium tuberculosis, from ESAT-6 to the antigen 85 complex, and assesses ...
How Parasitic Worms’ Brain Chemistry Could Yield the Next Generation of Worm-Killing Drugs
A new perspective proposes a pathway-to-phenotype framework for mapping bioaminergic GPCR signaling in parasitic flatworms, aiming to turn neurotransmitter biology ...
Electric Fish Reveal Hidden Brain Side Effects of a Common Cough Suppressant
A new quadrimodal assay using weakly electric fish detected dose-dependent brain effects of dextromethorphan, offering drug developers an early warning ...
Plant Compounds Emerge as Multitarget Leads Against Alzheimer’s Disease in Virtual Screen
A computational screen of 2,847 plant compounds against ten Alzheimer's-related proteins identified 36 multitarget phytochemicals with stable binding and literature-backed ...
One Wet-Lab Measurement May Be Enough to Steer AI-Designed ALS Gene-Silencing Drugs
A biophysics-informed machine learning framework predicts how effectively antisense oligonucleotides knock down ALS-relevant genes using only a single experimental measurement ...
Scientists Build Screening Toolkit to Find Bait Ligands for Antibacterial Protein Degradation Drugs
Researchers have developed fluorescence polarization and thermal shift screening methods to identify small-molecule bait ligands for the bacterial ClpC N-terminal ...
BMC Pharmacology and Toxicology Opens Call for New Editorial Board Members
BMC Pharmacology and Toxicology is recruiting new Editorial Board Members to handle rising submissions while maintaining validity-focused, open access peer ...
BMC Pharmacology and Toxicology Opens Call for New Editorial Board Members
BMC Pharmacology and Toxicology is recruiting new Editorial Board Members across five disciplines to sustain peer-review quality amid rising submissions.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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