Scientists Reveal Hidden Clustering Switch That Amplifies Lymphatic Vessel Growth Signals
KAIST and IBS researchers have determined the 3D structure of the VEGF-C–VEGFR-3 complex and shown that receptor clustering acts as ...
Tag: cryo-EM
Cells Tag Faulty Glycogen for Destruction, Study Reveals
Researchers have discovered that the E3 ubiquitin ligase RNF213 directly tags aberrant, poorly branched glycogen for autophagic degradation, revealing a ...
Human Mitochondrial Barrel Factory Caught in Two States by Cryo-EM
Cryo-electron microscopy has revealed monomeric and interlocked dimeric structures of the human mitochondrial SAM complex, showing that a conserved beta-barrel-switching ...
Fungal cell wall machine exposed: chitin synthase channel offers new antifungal target
Cryo-EM structures of the essential Candida albicans enzyme Chs1 reveal that a small-molecule inhibitor jams the chitin translocation channel, a ...
New Synthetic Nanobody Library Streamlines Cryo-EM Studies of Small Proteins
Researchers have engineered S1.0, a ribosome-display synthetic nanobody library that yields high-affinity binders compatible with the Legobody cryo-EM toolkit without ...
Cryo-EM Reveals How TB Drugs Target the Bacterial Cell Wall Epimerase Complex
Cryo-electron microscopy structures of the Mycobacterium tuberculosis DprE1–DprE2 epimerase complex reveal its tetrameric architecture and the precise binding modes of ...
Scientists Build Custom Protein Add-Ons to Rewire a Nanopore’s Electrical Behavior
Researchers have designed new protein subunits that integrate with a natural nanopore to create semisynthetic conduction pores with confirmed lumen ...
Cryo-EM Reveals How Polycomb Repressive Complex 1 Assembles, Works and Finds Its Targets
Ciapponi and colleagues have determined the cryo-EM structure of the canonical PRC1 holocomplex, revealing how its architecture coordinates assembly, H2A ...
Four Decades of Hunting the Misfolded Protein: How Prion Research Grew Into a Blueprint for Neurodegenerative Drug Design
A new review in Acta Neuropathologica chronicles four decades of Byron Caughey's pioneering work on prion disease inhibitors, from infrared ...
Cryo-EM Reveals How ATP Switches Off the Human NLRP6 Inflammasome
Cryo-EM structures of human NLRP6 in ATP-bound and unbound conformations reveal how ATP serves as an endogenous inhibitor of inflammasome ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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