Cellular chaperone EMC found essential for building calcium channels
Researchers report that the human EMC complex acts as a cotranslational chaperone for voltage-gated calcium channels, and that blocking this ...
Tag: cryo-EM
Cryo-EM reveals how a retrotransposon and CRISPR–Cas9 team up to insert genes
Cryo-electron microscopy structures of the zebra finch R2 retrotransposon, alone and bound to Cas9, reveal how target-primed reverse transcription initiates ...
Scientists Solve Structure of the Transporter That Packs GABA and Glycine Into Brain Vesicles
Cryo-EM structures of human VIAAT reveal how the transporter recognizes both GABA and glycine and how chloride and proton binding ...
AI Takes Over Cryo-EM: Deep Neural Networks Now Automate Particle Picking, Map Reconstruction and Atomic Modelling
A comprehensive review details how deep neural networks are automating every stage of cryo-electron microscopy, from particle picking to high-resolution ...
Vitrobot-based protocol makes graphene oxide cryo-EM grids reproducible and accessible
A new Vitrobot-based protocol produces graphene oxide cryo-EM grids with 55 percent average coverage and supports apoferritin and β-galactosidase reconstructions ...
Cryo-EM reveals how unrelated phage peptides converge on the same bacterial target
A new cryo-EM structure shows how the phage lysis protein SglPP7 locks the essential transporter MurJ in an outward-facing state, ...
Cryo-EM freezes bacterial enzyme mid-action as it builds a cancer drug scaffold
Cryo-electron microscopy reveals the bacterial enzyme SacC, which builds the five-ring core shared by the anticancer drug trabectedin, stabilized by ...
Cargo proteins act as molecular bridges that drive AP-1 coat assembly
A new study shows that cargo peptides physically bridge neighboring AP-1 adaptor complexes through a µ1–σ1 interface, revealing that cargo ...
Supercomputers Catch GPCRs in Motion, Reshaping Drug Discovery
Enhanced sampling molecular dynamics simulations are revealing the hidden intermediate states, allosteric networks, and kinetic pathways that static structures cannot ...
Cryo-EM snapshots expose the molecular machine that keeps deadly tropical parasites alive
Researchers at the University of Liège and Rockefeller University have captured near-atomic-resolution cryo-EM structures of the trans-spliceosome, the essential RNA-processing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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