Cell’s Insert and Undo Machines Caught Working Together in One ER Supercomplex
Cryo-EM structures reveal that the ER membrane protein complex and the Spf1 ATPase form a conserved supercomplex that juxtaposes membrane ...
Tag: cryo-EM
First-in-class NVL inhibitors starve tumors by blocking ribosome assembly
Researchers have developed the first selective inhibitors of the NVL ATPase, blocking 60S ribosomal subunit assembly to activate p53 and ...
How HIV-1’s Vpr Protein Hijacks a Human Degradation Machine to Destroy Diverse Targets
New cryo-EM structures reveal how the HIV-1 protein Vpr reshapes the human CRL4(VprBP) E3 ligase to degrade host substrates of ...
Cryo-EM Exposes Hidden Architecture of a Bacterial Antiviral Weapon Found in Pathogens
Cryo-electron microscopy has revealed the first structure of a TenpIN type III toxin-antitoxin complex common to several pathogenic bacteria, showing ...
Lithium Blocks the Cellular Channels That Let Fungi Survive Fluoride
New research shows that lithium ions competitively block the sodium-dependent activation of eukaryotic fluoride exporter channels, constricting their pores and ...
H5N1 Variants From a Severe Human Case Show Weakened Grip on Host Receptors
Cryo-EM and binding assays reveal that hemagglutinin mutations E190D and Q226H in H5N1 viruses from a severely ill British Columbia ...
Cryo-EM Captures the Step-by-Step Activation of the MERS-CoV Spike Protein
Time-course cryo-electron microscopy has revealed the sequence of structural changes by which DPP4 receptor binding progressively activates the MERS-CoV spike ...
Chemotherapy drug taxol reshapes microtubules to switch on a key cell signal
New research shows that taxane chemotherapy drugs expand the microtubule lattice and thereby release the signalling protein GEF-H1, rapidly activating ...
Graphene Reservoirs Bring Precise Ice Thickness Control to Cryo-EM
Researchers have engineered sagging graphene reservoirs that confine liquid films to precise, reproducible nanometer-scale thicknesses, solving a decades-old bottleneck in ...
Ancient Microbe’s Nitrogenase Caught in Action by Cryo-EM Reveals a Giant Off-Switch Supercomplex
The first cryo-EM structure of a native archaeal nitrogenase reveals a giant PII-bridged supercomplex that locks the enzyme inactive until ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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