Human Mitochondrial Barrel Factory Caught in Two States by Cryo-EM
Cryo-electron microscopy has revealed monomeric and interlocked dimeric structures of the human mitochondrial SAM complex, showing that a conserved beta-barrel-switching ...
Tag: cryo-EM
Fungal cell wall machine exposed: chitin synthase channel offers new antifungal target
Cryo-EM structures of the essential Candida albicans enzyme Chs1 reveal that a small-molecule inhibitor jams the chitin translocation channel, a ...
New Synthetic Nanobody Library Streamlines Cryo-EM Studies of Small Proteins
Researchers have engineered S1.0, a ribosome-display synthetic nanobody library that yields high-affinity binders compatible with the Legobody cryo-EM toolkit without ...
Cryo-EM Reveals How TB Drugs Target the Bacterial Cell Wall Epimerase Complex
Cryo-electron microscopy structures of the Mycobacterium tuberculosis DprE1–DprE2 epimerase complex reveal its tetrameric architecture and the precise binding modes of ...
Scientists Build Custom Protein Add-Ons to Rewire a Nanopore’s Electrical Behavior
Researchers have designed new protein subunits that integrate with a natural nanopore to create semisynthetic conduction pores with confirmed lumen ...
Cryo-EM Reveals How Polycomb Repressive Complex 1 Assembles, Works and Finds Its Targets
Ciapponi and colleagues have determined the cryo-EM structure of the canonical PRC1 holocomplex, revealing how its architecture coordinates assembly, H2A ...
Four Decades of Hunting the Misfolded Protein: How Prion Research Grew Into a Blueprint for Neurodegenerative Drug Design
A new review in Acta Neuropathologica chronicles four decades of Byron Caughey's pioneering work on prion disease inhibitors, from infrared ...
Cryo-EM Reveals How ATP Switches Off the Human NLRP6 Inflammasome
Cryo-EM structures of human NLRP6 in ATP-bound and unbound conformations reveal how ATP serves as an endogenous inhibitor of inflammasome ...
University of Cincinnati Structural Biologists Achieve World First in Visualizing Crucial Cell Protein
University of Cincinnati structural biologists have achieved a groundbreaking milestone in molecular biology by visualizing the intricate structure of a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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