How Tumor Mechanics Control Whether Mitochondrial DNA Fuels or Fights Cancer Immunity
A new review in the Journal of Translational Medicine proposes that the physical mechanics of solid tumors govern whether mitochondrial ...
Tag: cGAS-STING
How Tumor Mitochondria Help Cancer Hide From the Immune System
A new review in the Journal of Translational Medicine details how mitochondrial metabolic reprogramming in tumor cells drives immune evasion ...
Leaking Mitochondrial DNA Emerges as a Central Engine of Cellular Aging
A new review in Biogerontology argues that leaking mitochondrial DNA activates the cGAS-STING innate immune pathway in senescent cells, sustaining ...
How Failing Cellular Housekeeping Fuels Brain Disease Through a Viral Alarm System
A new review in the Journal of Translational Medicine details how impaired mitophagy allows mitochondrial DNA to trigger cGAS–STING-driven neuroinflammation ...
Common Bile Acid Drug Unlocks a Hidden Human Brake on Radiation-Driven Cancer Immunity
Researchers have identified a human-specific FXR-TRIM22-STAT1 checkpoint that suppresses radiation-induced antitumor immunity, and shown that the clinically approved bile acid ...
Tiny RNA Hubs May Steer Inflammation in Aging Cells
A new review argues that stress granules and their RNA-binding proteins act as context-dependent modulators of cellular senescence and inflammation ...
NAD+ Collapse Drives Senescent CD8+ T Cells That Worsen Ulcerative Colitis
A new study in Aging Cell shows that NAD+ metabolic collapse drives senescent CD8+ T cells to fuel ulcerative colitis ...
Ribonucleotides Supercharge Cancer Chemotherapy Through Mitochondrial DNA Stress
Researchers found that the natural nucleotide CMP dramatically amplifies floxuridine-driven cGAS–STING antitumor immunity and packaged the pair into nanoparticles that ...
Umbilical Cord Stem Cell Secretome Reverses Skin Aging by Boosting Mitophagy
A cell-free secretome from human umbilical cord stem cells reverses UV-induced skin photoaging in mice and keratinocytes by restoring mitophagy ...
How Aging Breaks the Timing of Skeletal Muscle Repair
A new review argues that aged skeletal muscle fails to regenerate not because any single cell type collapses but because ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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