TREX1 enzyme shields tumors by destroying immune-activating DNA fragments
New research shows that the TREX1 exonuclease suppresses anti-tumor immunity in mice by degrading short, MRE11-derived cytosolic DNA fragments that ...
Tag: cGAS-STING
Mitochondrial Damage May Drive Varicocele Infertility Through Oxidative Stress and Sterile Inflammation
A narrative review proposes that mitochondrial injury links varicocele-related oxidative stress and sterile inflammation, while stressing that the full pathway ...
DNA Sensor cGAS-STING Emerges as Double-Edged Driver of Acute Pancreatitis
A new review synthesizes evidence that the cGAS-STING DNA-sensing pathway both amplifies and restrains the inflammation and cell death that ...
Mitochondrial Cristae Emerge as Therapeutic Target in Ischemic Stroke
A new review examines how the folded inner membranes of mitochondria remodel during ischemic stroke and identifies molecular assemblies that ...
Aging DNA alarm links cellular stress to persistent brain inflammation
A literature review links age-related DNA leakage and persistent cGAS–STING signaling to chronic brain inflammation across several neurological disorders.
How Antiviral Innate Immunity Shapes Viral Myocarditis Outcomes
A new review maps how RNA- and DNA-sensing innate immune pathways determine whether cardiotropic viral infection resolves or progresses to ...
Tapeworm Protein Dampens Immune Alarm to Limit Heart Reperfusion Injury in Mice
In a mouse study, a recombinant Echinococcus granulosus protein shifted macrophages toward a repair-associated state by dampening the cGAS–STING pathway ...
Framework Separates DNA-Sensing Claims by Cell Type and Disease Stage
A focused review finds that cGAS–STING and AIM2 claims in atherosclerosis depend on the DNA source, cellular lineage, disease stage ...
Mitochondria Emerge as the Central Hub Driving Diabetic Nerve Damage
A new review argues that mitochondrial dysfunction is the central mechanism linking metabolic stress, inflammation, and nerve degeneration in diabetic ...
Cataract Clouding in Diabetes Traced to a DNA-Sensing Inflammatory Chain Reaction
Researchers at Sun Yat-sen University show that blocking the cGAS-STING pathway and the NLRP3 inflammasome reduces inflammatory cell death and ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!