Aging DNA alarm links cellular stress to persistent brain inflammation
A literature review links age-related DNA leakage and persistent cGAS–STING signaling to chronic brain inflammation across several neurological disorders.
Tag: cGAS-STING
How Antiviral Innate Immunity Shapes Viral Myocarditis Outcomes
A new review maps how RNA- and DNA-sensing innate immune pathways determine whether cardiotropic viral infection resolves or progresses to ...
Tapeworm Protein Dampens Immune Alarm to Limit Heart Reperfusion Injury in Mice
In a mouse study, a recombinant Echinococcus granulosus protein shifted macrophages toward a repair-associated state by dampening the cGAS–STING pathway ...
Framework Separates DNA-Sensing Claims by Cell Type and Disease Stage
A focused review finds that cGAS–STING and AIM2 claims in atherosclerosis depend on the DNA source, cellular lineage, disease stage ...
Mitochondria Emerge as the Central Hub Driving Diabetic Nerve Damage
A new review argues that mitochondrial dysfunction is the central mechanism linking metabolic stress, inflammation, and nerve degeneration in diabetic ...
Cataract Clouding in Diabetes Traced to a DNA-Sensing Inflammatory Chain Reaction
Researchers at Sun Yat-sen University show that blocking the cGAS-STING pathway and the NLRP3 inflammasome reduces inflammatory cell death and ...
How Ancient Chinese Medicine Compounds Rewire the Brain’s DNA Alarm System
A new review maps how traditional Chinese medicine compounds, herbal formulas, and electroacupuncture modulate the cGAS-STING neuroimmune pathway, revealing that ...
DNA Damage Response Drives PD-L1 Shield That Lets Aging Cells Evade Immune Clearance
A new review proposes that the DNA damage response drives PD-L1 upregulation in senescent cells, enabling immune evasion and creating ...
Microglia-Mimicking Nanoparticles Deliver CO and GSDME to Fire Up Glioblastoma Immunotherapy
A biomimetic nanoplatform cloaked in microglial cell membranes delivers carbon monoxide, manganese ions, and Gasdermin E across the blood-brain barrier ...
Immune Cells in the Ovary May Hold the Key to Slowing Female Reproductive Aging
A new review in the Journal of Ovarian Research argues that age-related shifts in ovarian macrophages, driven by pathways such ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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