RNF152 Tags PD-L1 for Destruction and Curbs Immune Evasion in Kidney Cancer
A study in Medical Oncology reports that the E3 ubiquitin ligase RNF152 is low in clear cell renal cell carcinoma, ...
Tag: CD8+ T cells
B cells organize tumor-killing T cells in mouse breast cancer study
A mouse breast cancer study found that CD40-stimulated B cells recruited CD8+ T cells into tumors, influenced their organization and ...
Chemokine Receptor CXCR5 Emerges as Tumor-Intrinsic Switch Controlling Chemo-Immunotherapy Response in Triple-Negative Breast Cancer
A new preclinical and retrospective clinical study reports that tumor-intrinsic CXCR5 coordinates CD8-positive T cell recruitment and p38-dependent apoptotic signaling, ...
Tetrandrine boosts ferroptosis and anti-PD-1 activity in mouse NSCLC models
Preclinical experiments found that tetrandrine promoted ferroptosis in NSCLC models, enhanced CD8⁺ T-cell effector responses and improved anti-PD-1 tumor suppression ...
ANKRD11 restrains CD8+ T cells in hepatitis B and cancer models
A mouse study found that removing ANKRD11 enhanced CD8+ T-cell activity against chronic hepatitis B virus infection and cancer, but ...
Early-onset colorectal cancer shows distinct immune-cell spatial patterns
A single-cell spatial analysis found similar overall immune-cell abundance but different local organization of regulatory and helper T-cell populations in ...
MerTK links dexamethasone to weakened antiviral immunity in chronic LCMV infection
A mouse study found that MerTK largely mediated dexamethasone-associated suppression of antiviral CD8+ T cells and increased LCMV dissemination during ...
Retrospective blood protein models predict outcomes in 38 HPV16 cancer patients
A retrospective study of 38 patients with advanced HPV16-positive cancers linked baseline and early serum protein measurements to outcomes from ...
Exploratory study links habitual activity to adrenergic regulation in aging T cells
A small exploratory human study associated habitual physical activity with adrenergic regulation of CD8+ T-cell glucose-transporter expression while finding that ...
Bladder Cancer Protein GSDMB Boosts Immunotherapy by Recruiting Immune Cells
A new study reveals that the protein GSDMB enhances anti-PD-1 immunotherapy in bladder cancer by driving Sema7a-mediated recruitment and activation ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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