How Low Oxygen Helps Neuroblastoma Turn Killer T Cells Off
New research shows that oxygen-starved neuroblastoma cells stabilize HIF-1α, which directly activates PD-L1 transcription and drives CD8+ T-cell dysfunction, a ...
Tag: CD8+ T cells
Light-based therapy triggers immune cure of thick pigmented melanoma in mice
A dual-photosensitizer light treatment combined with optical clearing eradicated thick pigmented melanoma in mice by triggering a potent, long-lasting anti-tumor ...
Intravenous STING Agonist Supercharges Radiotherapy to Trigger Anti-Tumour Immunity
A novel intravenous STING agonist, BI 1703880, synergises with radiotherapy and checkpoint inhibitors to generate durable anti-tumour immunity in preclinical ...
Immune-cell switch flips the metabolic war between tumors and T cells in immunotherapy-resistant cancers
A new study shows that activating the lipid sensor PPARδ in immune cells rather than cancer cells flips the metabolic ...
Immune Cells That Attack the Heart: Multi-Omics Study Reveals Signature of Checkpoint Inhibitor Myocarditis
A multi-omics study identifies ISG15-positive CD8 T cells and a CCL2-CCR2-mediated inflammatory loop as drivers of immune checkpoint inhibitor-induced myocarditis, ...
Scientists uncover how tobacco rewires head and neck cancer metabolism through a single mucin molecule
New research reveals that tobacco carcinogens lift a GATA4-mediated brake on the mucin MUC5B, driving fatty acid metabolism and immune ...
Cell Therapy Takes Aim at Rare Nerve Tumors in New Preclinical Breakthrough
Researchers have developed an optimized tumor-infiltrating lymphocyte manufacturing protocol that shows preclinical efficacy against NF1- and schwannomatosis-related nerve sheath tumors, ...
PET tracer lights up ferroptosis to track liver cancer immunotherapy in real time
Researchers combined anti-PD-L1 immunotherapy with the PARP inhibitor Olaparib to trigger ferroptosis in liver cancer and used the SLC7A11-targeted PET ...
How aging and sex reshape the immune system’s fight against cancer
A new Nature Aging study from Mass General Brigham shows that male and female immune systems age differently, with earlier ...
A Shrinking Thymus May Blunt Cancer Immunity in Middle-Aged Men
New research in Nature Aging shows that accelerated loss of naive CD8+ T cells in middle-aged male mice shrinks lymph ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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