NAD+ Collapse Drives Senescent CD8+ T Cells That Worsen Ulcerative Colitis
A new study in Aging Cell shows that NAD+ metabolic collapse drives senescent CD8+ T cells to fuel ulcerative colitis ...
Tag: CD8+ T cells
Gut Microbe’s Stress-Linked Metabolite Drives Breast Cancer Spread, and an Ancient Drug Blocks It
New research traces how chronic stress fuels breast cancer metastasis through a gut bacterium's tryptophan metabolite and shows that the ...
Immune Cells Cluster, Not Crowd, in Melanoma That Spreads to the Brain
A Dutch study finds that melanoma brain metastases harbor far fewer but more tightly clustered immune cells than other metastases, ...
Melanoma’s Genetic Blueprint Builds Immune-Proof Tumor Neighborhoods, Study Finds
Researchers at NYU Grossman School of Medicine show that loss of the NF1 tumor suppressor reorganizes melanoma tumors into immunosuppressive ...
Sugar Signature Reveals Which Tumor-Fighting T Cells Are Most Vulnerable
Researchers at Peking University have developed a single-cell method showing that low α2,6-linked sialylation marks the most potent tumor-reactive CD8+ ...
Engineered fusogenic vaccinia virus arms IL-15 to reprogram tumors and boost antitumor immunity
Researchers engineered a fusogenic oncolytic vaccinia virus that displays IL-15Rα on infected tumor cells to locally trans-present IL-15, reprogramming the ...
Serum Asparagine Emerges as a Molecular Signature of Childhood Asthma in Preschoolers
A targeted metabolomic study of 113 Polish preschool children found that serum asparagine and alpha-aminobutyric acid levels distinguish children with ...
PD-1 and LAG-3 Double-Positive T Cells Predict Better Gastric Cancer Survival
A multicohort study finds that gastric tumors rich in PD-1 and LAG-3 double-positive CD8 T cells—an activated, pre-exhausted population—are linked ...
Gut Bacteria Sugar Turns Itself Into a Cancer Vaccine Supercharger
Scientists have transformed a sugar molecule produced by gut bacteria into a self-assembling nanovaccine that dramatically boosts antitumor immunity and ...
Cell Death Turns Tumors Against Themselves in Combo Therapy for Pancreatic Neuroendocrine Cancer
New research shows that combining sunitinib with 177Lu-DOTATATE radiotherapy triggers immunogenic cell death in pancreatic neuroendocrine tumors, recruiting antitumor T ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!