CD4 T Cell Help Powers Immunotherapy Response in Tumors Lacking MHC-I
Mouse experiments show that CD4+ T cells license CD8+ T cells through CD40 signaling, enabling combination immunotherapy to eliminate mismatch ...
Tag: CD8+ T cells
Recombinant HPV16 E7 vaccine plus CD137 agonism clears tumors in mice
A recombinant overlapping peptide vaccine targeting HPV16 E7, combined with 4-1BB agonist antibody, eradicated established tumors in most treated mice ...
Bladder cancer immune landscape is compartmentalized, treatment-modified, and context dependent
A new narrative review finds that the clinical meaning of immune infiltration in bladder cancer depends on cell localization, functional ...
Biomaterials Target Cholesterol Metabolism to Exploit Cancer Cell Vulnerabilities
A new review maps how biomaterials can exploit cholesterol metabolism in cancer while warning that most mechanistic claims remain unproven.
New chimeric antibodies turn marmosets into a working KSHV infection model
Two newly developed mouse–marmoset chimeric monoclonal antibodies enabled controlled T cell depletion in common marmosets, revealing KSHV lytic replication and ...
Engineered Bacteria Deliver Two-in-One Immunotherapy Directly to the Pleural Cavity in Mice
An engineered non-pathogenic bacterium carrying a PD-L1 blocker and IL-15 significantly suppressed pleural tumors and fluid buildup in a mouse ...
RNF152 Tags PD-L1 for Destruction and Curbs Immune Evasion in Kidney Cancer
A study in Medical Oncology reports that the E3 ubiquitin ligase RNF152 is low in clear cell renal cell carcinoma, ...
B cells organize tumor-killing T cells in mouse breast cancer study
A mouse breast cancer study found that CD40-stimulated B cells recruited CD8+ T cells into tumors, influenced their organization and ...
Chemokine Receptor CXCR5 Emerges as Tumor-Intrinsic Switch Controlling Chemo-Immunotherapy Response in Triple-Negative Breast Cancer
A new preclinical and retrospective clinical study reports that tumor-intrinsic CXCR5 coordinates CD8-positive T cell recruitment and p38-dependent apoptotic signaling, ...
Tetrandrine boosts ferroptosis and anti-PD-1 activity in mouse NSCLC models
Preclinical experiments found that tetrandrine promoted ferroptosis in NSCLC models, enhanced CD8⁺ T-cell effector responses and improved anti-PD-1 tumor suppression ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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