RBBP5 Emerges as a Master Epigenetic Switch Controlling the Cell’s 12-Hour Proteostasis Clock
A new PLOS Biology study identifies the COMPASS complex subunit RBBP5 as the central epigenetic regulator of the cell's 12-hour ...
Tag: autophagy
Machine Learning Maps How Environment and Immunity Shape Childhood Eczema Risk
A machine learning analysis of 217 South African AmaXhosa children has identified one protective and two susceptibility clusters linking rural ...
ZBED6 Loss Fuels Pathological Heart Enlargement Through a Newly Mapped Gene Switch
New research in PLOS Genetics identifies the ZBED6–MEOX1–ERK1/2 axis as a key regulator of pathological cardiac hypertrophy through impaired autophagy.
Single GTPase Governs a Strange Autophagy-Like Pathway in the Parasite Giardia
Researchers have discovered that Giardia lamblia runs an ATG8-independent autophagy-like pathway regulated by its sole Rho GTPase, GlRac, revealing a ...
How Pathogens Hijack Mitophagy and What It Means for Treating Infection
A new review details how bacteria and viruses hijack or block the mitochondrial quality-control pathway of mitophagy to survive, evade ...
Bacterial Toxin Hijacks Mitochondria to Trigger Fatal Cell Death in Bovine Mastitis
New research reveals that the Staphylococcus aureus virulence factor Sph disrupts mitochondrial cristae through Mic60, releasing mtDNA that activates the ...
Diabetes Drugs May Ease Pulmonary Hypertension by Taming Activin A Signaling
A new study links SGLT2 inhibitor therapy with reduced circulating activin A, improved right-heart function, and modulation of BMP/activin signaling ...
Blocking a Single Protein Makes Childhood Cancer Cells Easier for Immunotherapy to Find
Penn State researchers found that blocking the protein VPS34 raises levels of the GD2 molecule on neuroblastoma cells, making them ...
Hidden Protein Networks Emerge as Central Players in Huntington’s Disease
A new review argues that Huntington's disease is driven by widespread disruptions of interconnected protein networks, pointing to hub proteins ...
Cellular Recycling Machine Linked to Male Fertility Hormone Control
New research reveals that the cellular recycling protein p97/VCP directly regulates the autophagic degradation of androgen-binding protein in Sertoli cells, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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