Curcumin Shows Promise Against Ovarian Cancer, but Nanotechnology May Hold the Key
A systematic review of 21 preclinical studies finds that curcumin and its nanoformulations modulate key cancer signaling pathways and enhance ...
Tag: apoptosis
Experimental Drug SMIP004 Hunts Down Dormant Cancer Cells Left Behind by Chemotherapy
Researchers report that the mitochondria-targeting compound SMIP004 selectively kills therapy-induced senescent cancer cells by promoting degradation of the AMPK-stabilized metabolic ...
Triaptosis: Scientists Unveil a New Form of Cell Death Centered on Endosomes
A new review in Cell Death & Discovery proposes triaptosis, an endosome-centered form of ROS-regulated cell death driven by oxidative ...
Old Antipsychotic Meets Mitochondrial Blocker in Two-Drug Strike on Cancer Cells
New research shows that pairing the decades-old antipsychotic chlorpromazine with the mitochondrial fission inhibitor mdivi-1 sharply boosts cancer cell death ...
Fatty Liver Cells Turn On a Caspase-2 Death Pathway That Damps Hepatitis B Replication
New in vitro research shows that free fatty acid–induced steatosis activates a TNF-α/TNFR1–Caspase−8/Caspase−2 apoptotic pathway that is associated with reduced ...
Scientists map the developing human heart cell by cell and reveal how Down syndrome disrupts it
A multimodal atlas of the developing human heart reveals 21 tissue niches, shows fetal pacemaker cells recruiting their own nerve ...
Scientists discover the molecular switch that lets TNF trigger cell death
A new study identifies the E3 ubiquitin ligase HERC4 as the long-sought molecular switch that licenses RIPK1 to initiate TNF-induced ...
Tiny vesicles in cancer patients’ blood rewire T cells and blunt immunity
Plasma-derived small extracellular vesicles from head and neck cancer patients suppress T-cell proliferation, trigger apoptosis, and rewire immune checkpoint expression ...
Cell Death Signature in Gut Lining Predicts Inflammatory Bowel Disease Relapse
A new study shows that a necroptotic-to-apoptotic cell death axis in intestinal epithelial cells, driven by TNF and interferon gamma, ...
Dead Bacteria, Living Protection: Heat-Killed Probiotic Blocks Inflammatory Cell Death to Heal Stomach Ulcers
Heat-killed Bifidobacterium animalis subsp. lactis BB-12 protected mice from indomethacin-induced gastric ulcers as effectively as live probiotics and better than ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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