Hidden RNA Errors Found at the Synapse in Frontotemporal Dementia
Multi-omic profiling of synaptosomes from C9ORF72-frontotemporal dementia brain and patient-derived neurons reveals widespread synaptic molecular disruption and, for the first ...
Tag: ALS
Blood Tau Rises in ALS but Tracks Motor Neuron Damage, Not Thinking Skills
A large multicenter study finds that plasma p-tau181, an approved Alzheimer's blood biomarker, is elevated in ALS and rises over ...
MRI, Genes and Single-Cell Data Point to Vulnerable Brain Regions in ALS
By integrating MRI, brain-wide gene expression and single-cell sequencing, researchers have identified MOBP and ZNHIT3 as candidate genes underlying region-specific ...
High-Flow Nasal Cannula Emerges as Lifeline for ALS Patients Who Cannot Tolerate Ventilation Masks
A retrospective case series of 18 ALS patients who could not tolerate non-invasive ventilation suggests that home-based high-flow nasal cannula ...
Human ALS Seeds Transmit Two Distinct SOD1 Aggregation Strains in Mice
Seeds prepared from the spinal cords of ALS patients homozygous for the SOD1 D90A mutation transmitted two distinct strains of ...
Glycolytic Enzyme Accelerates ALS by Fueling Inflammatory Neuron Death
New research shows that loss of TDP-43 in ALS drives the glycolytic enzyme ALDOA to trigger inflammatory pyroptotic death of ...
Could Predatory Brain Immune Cells Be Destroying Nerve Cells in ALS?
Amyotrophic lateral sclerosis (ALS) has traditionally been described as a disease of motor neurons—the nerve cells that carry signals from ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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