Return exactly one rewritten English science news headline for the original title below. Maximum 12 words. Output plain text only. Do not use HTML, Markdown, quotes, labels, explanations, bullets, numbering, or multiple options. Original title: Tumor immune cell targeting chimeras reprogram tumor-associated macrophages

Immune cells in the tumor microenvironment are not only powerful regulators of immunosuppression and tumorigenesis but also a dominant cell population, with tumor-associated macrophages (TAMs) comprising up to 50% solid tumor mass. Immunotherapies such as immune checkpoint inhibitors derive efficacy from this cancer–immune interface; however, immune-related adverse events from systemic blockade remain a major challenge. To address this need for potent, tumor-specific immunotherapies, we developed tumor immune cell targeting chimeras (TICTACs) that selectively deplete immune checkpoint receptors such as SIRPα from TAM surfaces. These chimeras consist of a synthetic ligand targeting CD206, a TAM marker, conjugated to a nonblocking antibody that binds to the checkpoint receptor without inhibiting it. By engaging CD206, which constitutively recycles between the plasma membrane and early endosomes, TICTACs drive robust checkpoint degradation in CD206^high macrophages, with no effect on CD206^low cells. This decoupling of antibody selectivity from blocking function presents a new paradigm for tumor-specific immunotherapies.

Morimoto, M., Roberts, D.S., Wen, R.M. et al. Tumor immune cell targeting chimeras reprogram tumor-associated macrophages.
Nat Chem Biol (2026). https://doi.org/10.1038/s41589-026-02258-2

https://doi.org/10.1038/s41589-026-02258-2 bu içeriği 600 ile 800 kelime arasında olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve Viral science news olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde 8 ile 10 paragraf olsun ve toplam uzunluk 600 ile 800 kelime arasında kalsın. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer bilgi yoksa ilgili kısmı yazma.:

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Morimoto, M., Roberts, D.S., Wen, R.M. et al. Tumor immune cell targeting chimeras reprogram tumor-associated macrophages.
Nat Chem Biol (2026). https://doi.org/10.1038/s41589-026-02258-2

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DOI: https://doi.org/10.1038/s41589-026-02258-2

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