SPP1 emerges as a master switch shaping the tumor immune landscape
A new review details how the matrix protein SPP1 orchestrates immunosuppression across the tumor microenvironment and outlines emerging strategies to ...
Tag: tumor-associated macrophages
Gut Microbes May Shape Glioblastoma Immunity, But Evidence Falls Short of Proof
A new review finds growing preclinical evidence that the gut microbiome can influence glioblastoma immunity, while warning that human evidence ...
Tumor Protein CEMIP Hijacks Immune Cells to Fuel Colorectal Cancer Drug Resistance
New research reveals that the tumor protein CEMIP drives extracellular vesicle output, reprograms macrophages by disrupting HSP90-JAK2 signaling, and enables ...
Three Cell Subclusters Uncovered as Drivers of Pancreatic Cancer Cachexia
University of Oklahoma researchers have identified three adjacent cell subclusters in pancreatic tumors that form a feed-forward network driving cancer ...
MRI Scans Reveal Hidden Cell Neighborhoods That May Signal Breast Cancer Spread
Researchers at Fudan University Shanghai Cancer Center have linked MRI-visible features such as background parenchymal enhancement and peritumoral edema to ...
Macrophages Take Center Stage: Rethinking Antibody-Driven Phagocytosis in Cancer Therapy
A new review argues that macrophage-mediated antibody-dependent cellular phagocytosis, long overshadowed by NK-cell killing, is the dominant effector mechanism behind ...
ATP-Sensing Receptor P2RX4 Emerges as a Molecular Window Into Triple-Negative Breast Cancer’s Immune Landscape
A multi-omics study links the ATP-gated receptor P2RX4, expressed mainly by tumor cells, to macrophage marker CD163 and hypoxia signatures ...
Miniature Brain Tumors in a Dish Offer New Hope for Beating Immunotherapy Resistance
A new review in the Journal of Translational Medicine describes how brain tumor organoid platforms are being used to reconstruct ...
Macrophage Gene Signatures Predict Colorectal Cancer Prognosis, Machine Learning Study Finds
By integrating bulk and single-cell RNA sequencing with machine learning, researchers in China have identified a nine-gene macrophage signature that ...
Simple Blood Inflammation Scores May Signal Spread of Vulvar Cancer
Two inflammation scores computed from routine blood counts were linked to lymph node metastasis and lymphovascular invasion in vulvar squamous ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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