Essential genetic mutations impair DNA damage repair and modulate tumor immune microenvironment in ccRCC
Clear cell renal cell carcinoma represents one of the most common and lethal subtypes of kidney cancer, characterized by distinct...
Scientists at UMass Chan Medical School develop microRNA-based gene therapy that halts ALS progression in mice
A single IV injection of a microRNA-based biologic developed by Guangping Gao, PhD; Robert H. Brown Jr., DPhil, MD; Jun...
Sungkyunkwan University research team successfully advances AI-designed base editors, paving the way for next-generation gene therapy
A joint research team led by Professor Daesik Kim (Department of Medicine, Sungkyunkwan University), along with Professor Yong-Sub Kim (University...
NIH grants $2.8M to develop tools for study of mosquito-microbe interactions
UNIVERSITY PARK, Pa. — Mosquito-borne pathogens, including zika, yellow fever and other illnesses have serious and worldwide impacts on human...
Nanopore sequencing identifies parent-of-origin specific age-associated methylation changes at imprinted loci in the human genome
Sigurpalsdottir, B., Holley, G., Sverrisson, S.Þ. et al. Nanopore sequencing identifies parent-of-origin specific age-associated methylation changes at imprinted loci in...
Deletion of ARPKD-associated Pkhd1 gene in mice results in decreased Tfap2b expression and eye abnormalities
Ishimoto, Y., Menezes, L.F., Nakaya, N. et al. Deletion of ARPKD-associated Pkhd1 gene in mice results in decreased Tfap2b expression...
In vivo CRISPR base editing for treatment of Huntington’s disease
Shirguppe, S., Gapinske, M., Swami, D. et al. In vivo CRISPR base editing for treatment of Huntington’s disease. Nat. Biomed....
Quorum sensing enables nitrite-oxidizing bacteria to fuel nitritation via altruism
Nitritation—turning ammonia into nitrite without pushing the reaction further—promises an energy-saving pathway for wastewater nitrogen removal. Yet the approach has...
Study Finds Small Genetic Mutation Causes Major Effects in Rare Heart Diseases
A new study suggests that two inherited cardiomyopathies—dilated cardiomyopathy (DCM) and left ventricular non-compaction (LVNC)—can diverge dramatically from an almost...
Multi-omics Study Uncovers How Androgen Deprivation Reprograms Testis Sertoli Cells
A new multi-omic study has mapped how the human testicular niche remodels when androgen signaling is abruptly removed, offering a...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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