In vivo CRISPR base editing for treatment of Huntington’s disease

Subject of Research: Medicine

Article Title: In vivo CRISPR base editing for treatment of Huntington’s disease

Article References: Shirguppe, S., Gapinske, M., Swami, D., Shenouda, K., Miskalis, A., Gosstola, N., Del Bosque Siller, D., Guerra, I., Acharya, P., Joulani, D., Szkwarek, M. G., Nambiar, A., Bhattacharjee, A., Dangi, A. S., Odle, N., Nathan, G. E., Elias, G., Stilger, M., Winter, J., ... Perez-Pinera, P. (2026). In vivo CRISPR base editing for treatment of Huntington’s disease. Nature Biomedical Engineering. https://doi.org/10.1038/s41551-026-01747-y

Image Credits: AI Generated

DOI: 10.1038/s41551-026-01747-y

Keywords: advancements in neurogenetic therapies, biomedical engineering in neurogenetics, CRISPR technology in Huntington’s disease, CRISPR-based gene correction in vivo, gene editing in neurodegenerative disorders, genome editing for hereditary neurological disorders, Huntington’s disease genetic mutation targeting, in vivo CRISPR base editing for Huntington’s disease treatment, in vivo gene therapy strategies, molecular mechanisms of Huntington’s disease, targeted genetic therapy for Huntington’s, therapeutic potential of CRISPR in neurodegeneration