Deletion of ARPKD-associated Pkhd1 gene in mice results in decreased Tfap2b expression and eye abnormalities

Subject of Research: Medicine

Article Title: Deletion of ARPKD-associated Pkhd1 gene in mice results in decreased Tfap2b expression and eye abnormalities

Article References: Ishimoto, Y., Menezes, L. F., Nakaya, N., Barbosa-Sabanero, K., Horie, Y., Yoshida, T., Reece, J. M., Zhou, F., Tomarev, S., Kerosuo, L., & Germino, G. G. (2026). Deletion of ARPKD-associated Pkhd1 gene in mice results in decreased Tfap2b expression and eye abnormalities. Nature Communications, 17(1), Article 8650. https://doi.org/10.1038/s41467-026-75698-y

Image Credits: AI Generated

DOI: 10.1038/s41467-026-75698-y

Keywords: ARPKD mouse model, ARPKD-associated gene function, congenital eye abnormalities, developmental eye defects in mice, eye abnormalities in genetic mouse models, gene knockout studies in mice, Pkhd1 and Tfap2b gene regulation, Pkhd1 gene deletion effects, polycystic kidney disease genetics, polycystic kidney disease research, renal and ocular phenotypes in ARPKD, Tfap2b gene expression changes