In recent years, the medical community has increasingly acknowledged the complexity of obesity as a risk factor for cardiovascular diseases, particularly heart failure (HF). While Body Mass Index (BMI) has long been the standard measure for assessing obesity, emerging research indicates that it may be insufficient to capture all relevant aspects of fat distribution that contribute to cardiovascular risk. At the forefront of this evolving understanding is the waist-to-height ratio (WtHR), a metric that directly reflects central adiposity — the accumulation of harmful visceral fat around vital organs. New compelling evidence now highlights WtHR as a superior predictor of incident heart failure compared to BMI, signaling a potential paradigm shift in cardiovascular risk assessment.
Presented at the prestigious European Society of Cardiology’s Heart Failure 2025 congress, recent findings from researchers at Lund University, Sweden, offer a groundbreaking perspective on the predictive power of WtHR. The study cohort included 1,792 individuals aged between 45 and 73 years drawn from the Malmö Preventive Project — a well-characterized epidemiological study designed to dissect risk factors for cardiometabolic diseases. Unlike earlier studies relying mainly on BMI, these researchers meticulously measured waist circumference relative to height, enabling a more precise evaluation of central obesity’s role in the pathogenesis of heart failure over a median 12.6-year follow-up period.
Heart failure represents a significant and escalating public health burden worldwide, characterized by impaired cardiac function and debilitating symptoms. Understanding modifiable risk factors for HF incidence is essential for effective prevention and treatment strategies. While BMI provides a broad categorization of obesity, it often fails to discern between muscle, subcutaneous fat, and visceral fat compartments, which have differing metabolic and cardiovascular impacts. Conversely, the WtHR offers a direct proxy for adiposity centered in the abdominal cavity — a known driver of systemic inflammation, insulin resistance, and neurohormonal activation, all pivotal mechanisms implicated in HF development.
In this rigorous longitudinal analysis, the investigators observed that higher waist-to-height ratios were robustly associated with an elevated risk of new-onset heart failure, even after adjusting for traditional confounders such as age, sex, diabetes status, and blood pressure. Specifically, a one standard deviation increase in WtHR corresponded to a 34% increase in hazard for incident HF. When stratifying participants by quartiles, those in the highest quartile with a median WtHR of 0.65 exhibited an almost threefold increased risk compared to those in the lower quartiles, emphasizing the profound prognostic significance of central adiposity beyond general obesity measures.
The implications of these findings are multifaceted. First, they reinforce the inadequacy of relying solely on BMI for cardiovascular risk stratification and highlight the merit of incorporating anthropometric measures that reflect fat distribution. Second, the median WtHR in the study was notably above the established cardiometabolic risk threshold of 0.5, a clear signal that many patients already present with detrimental fat patterns many years before HF diagnosis. Current clinical guidelines may benefit from integrating WtHR as a screening tool to identify at-risk individuals who might otherwise be missed by BMI-centric assessments.
Mechanistically, visceral fat exerts deleterious effects through the secretion of bioactive molecules, including adipokines, pro-inflammatory cytokines, and free fatty acids. These factors contribute to endothelial dysfunction, oxidative stress, and myocardial remodeling — key processes that precede and propagate heart failure syndromes. Unlike peripheral adiposity, which may confer neutral or even protective effects in some contexts, central adiposity tracked by WtHR is closely tied to metabolic dysregulation, underscoring the pathophysiological rationale behind the observed associations.
Moreover, while prior research has paradoxically noted a protective association of higher BMI with better HF outcomes – a phenomenon often referred to as the “obesity paradox” – such paradoxical effects were not observed with WtHR. This distinction suggests that WtHR might offer more consistent and biologically plausible risk estimates, avoiding confounding by lean mass or other non-adiposity factors inherent in BMI measurements. Clinical practitioners should consider this differential when evaluating patients with or at risk for HF to better tailor preventive and therapeutic interventions.
The researchers also note that the study population included a spectrum of individuals with normal glucose metabolism, impaired fasting glucose, and established diabetes, all of which influence cardiovascular health. The persistent predictive value of WtHR across these subgroups solidifies its role as a universal marker transcending glycemic status and supports its broad applicability in varied clinical settings. This is particularly relevant in an aging population where diabetes and obesity frequently coexist, exacerbating cardiovascular risk.
Looking ahead, the research team is planning to extend their work by examining larger, more diverse cohorts to validate and expand these findings. They aim to evaluate whether WtHR can predict not only heart failure but a wider array of cardiometabolic conditions with similarly strong associations. Given the simplicity and cost-efficiency of measuring WtHR in clinical practice, future studies could pave the way for routine adoption of this metric, enhancing early detection and intervention strategies for cardiovascular disease prevention.
Furthermore, the study’s lack of specific funding and absence of competing disclosures affirm its impartiality and underscore an authentic pursuit of advancing cardiovascular knowledge based on robust epidemiological evidence. The collaboration between Lund University and Malmö University Hospital represents a meaningful integration of academic and clinical expertise towards impactful research outcomes.
This emerging evidence invites a fresh look at obesity-related cardiovascular risk assessment and underscores the necessity of refining anthropometric tools. Waist-to-height ratio, by capturing central adiposity with greater precision, emerges as a promising candidate to complement or even supplant BMI in certain contexts, particularly for heart failure risk prediction. Integrating WtHR into clinical algorithms could revolutionize preventive cardiology by enabling more targeted identification of high-risk patients and personalized management plans.
In conclusion, this novel analysis positions waist-to-height ratio as a critical and reliable predictor of incident heart failure, challenging the dominance of BMI in obesity evaluation. As the global epidemic of obesity continues to fuel cardiovascular morbidity and mortality, innovative and precise metrics such as WtHR offer hope for improved risk stratification and ultimately better patient outcomes. These findings merit attention from clinicians, researchers, and health policymakers striving to curb the tide of heart failure worldwide.
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Subject of Research: Waist-to-height ratio as a predictor of incident heart failure
Article Title: Waist-to-height ratio predicts heart failure incidence, new evidence from the Malmö Preventive Project
News Publication Date: 18 May 2025
Web References:
– Presentation at Heart Failure 2025 ePosters (European Society of Cardiology): https://esc365.escardio.org/Heart-Failure/sessions/14908-eposters-in-chronic-heart-failure-epidemiology-prognosis-outcome-3
– Lund University and European Society of Cardiology websites
References:
1. Savji N, Meijers WC, Bartz TM, et al. The association of obesity and cardiometabolic traits with incident HFpEF and HFrEF. JACC Heart Fail. 2018;6:701–709.
2. Peikert A, Vaduganathan M, Claggett BL, et al. Near-universal prevalence of central adiposity in heart failure with preserved ejection fraction: the PARAGON-HF trial. Eur Heart J. 2025 Jan 28: ehaf057.
Image Credits: Not available
Keywords: Cardiology, Physical exercise, Obesity, Heart failure, Anthropometric measures, Waist-to-height ratio, Cardiometabolic risk, Central adiposity
