Tag: tumour microenvironment

A new review argues that antibody–drug conjugates act as immune modulators through immunogenic cell death, Fc-mediated effector functions and tumour ...

The first single-cell RNA sequencing study of naturally occurring insulinoma in any species reveals two distinct insulin-expressing cancer cell populations, ...

By integrating bulk and single-cell RNA sequencing with machine learning, researchers in China have identified a nine-gene macrophage signature that ...

A new review in Medical Oncology synthesises evidence that tumours form functional synapses with neurons and exploit autonomic signalling to ...

A landmark review argues that tumour-agnostic immunotherapy succeeds only when biological rationale, validated biomarkers and health-system infrastructure are aligned, using ...

Researchers have introduced the Spatial Immune Barrier Index, a spatial transcriptomics measure that quantifies the suppressive barrier holding immune cells ...

A new MRI-readable nanoparticle sensor shows that abrupt surges of mechanical stress, rather than cumulative load, trigger epithelial–mesenchymal transition in ...

Researchers have developed DePass, a dual-enhanced graph learning framework that iteratively denoises and integrates paired multi-omics data across single-cell and ...

University of Sheffield researchers found that type I collagen in tumour scaffolding lets breast and pancreatic cancer cells switch fuel ...

A new review in Nature Reviews Neurology synthesizes evidence that gut and oral microbes, and even bacteria residing within brain ...