Lipid metabolism reprogramming offers emerging routes to treating liver cancer
A peer-reviewed review identifies altered lipid uptake, synthesis, oxidation and storage as drivers of hepatocellular carcinoma and possible therapeutic targets, ...
Tag: tumour microenvironment
Preclinical study identifies ascites targets and tests E8 nanobody in peritoneal metastases
A preclinical Singapore study identified PAI-1 and S100A10 as ascites-associated drivers of peritoneal metastases and found that the PAI-1-targeting nanobody ...
Mechanisms by which programmed cell death mediates immune evasion and antitumour immunity in oropharyngeal cancer
A review finds that programmed cell death can promote immune evasion or antitumour immunity in oropharyngeal cancer depending on pathway ...
Nanocarriers Under Pressure: New Review Charts Path to Stable Polymeric Micelle Drugs
A new review in Advanced Composites and Hybrid Materials explains why polymeric micelle drug carriers remain fragile in the bloodstream ...
Kidney Cancer’s Metabolic Rewiring Exposes New Drug Targets
A review in Genes & Diseases maps how VHL loss drives metabolic reprogramming in clear cell renal cell carcinoma and ...
Fibroblast collagen signal drives gut scarring and cancer in inflammatory bowel disease
A single-nuclei study reveals how CXCL14+ fibroblasts and SPP1+ macrophages form a collagen IV-driven feedback loop that promotes fibrosis and ...
Single-Cell Study Pinpoints OTUD7B as a Master Switch Behind Pancreatic Cancer’s Defenses
A multiomics study identifies the deubiquitinase OTUD7B as a central driver of epithelial remodelling, mitochondrial reprogramming, and immune suppression in ...
Canine Distemper Virus Rewrites Gene Activity in Histiocytic Sarcoma Cells Across Simulated Tumour Zones
RNA sequencing reveals that persistent canine distemper virus infection reshapes immune, angiogenic, and metabolic gene expression in canine histiocytic sarcoma ...
Intravenous STING Agonist Supercharges Radiotherapy to Trigger Anti-Tumour Immunity
A novel intravenous STING agonist, BI 1703880, synergises with radiotherapy and checkpoint inhibitors to generate durable anti-tumour immunity in preclinical ...
How Nutrient Availability Rewires Mitochondria and Cytoskeleton in 3D Lung Cancer Models
A new systems-level study in 3D lung adenocarcinoma models shows that nutrient availability drives tumour cells into two distinct mitochondrial ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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