How the Bone Marrow Niche Shields Acute Myeloid Leukemia From Chemotherapy
A comprehensive review reveals how leukemic cells hijack the bone marrow microenvironment to survive chemotherapy, highlighting the CXCL12–CXCR4 axis, stromal ...
Tag: tumor microenvironment
Why the Immune System Fails Some Bladder Cancers and How Scientists Are Fighting Back
A new review explains why BCG immunotherapy fails in some bladder cancer patients and outlines emerging combination strategies designed to ...
AI-Guided Peptide Design Targets Fibroblast Activation Protein in Rectal Cancer
A computational study identified fibroblast activation protein as the top stromal target in rectal cancer and designed a peptide inhibitor ...
How Persistent HPV Infection Drives Cervical Precancer: Molecular Pathways, Immune Evasion and Emerging Technologies
A new review in Cellular and Molecular Life Sciences maps the molecular pathways, immune microenvironment and AI-driven technologies that shape ...
Gut Microbes and Lung Cancer: Genes Point to Six Suggestive Links, But Butyrate Experiments Steal the Show
A Mendelian randomization study of 119 gut microbial genera finds six suggestive inverse associations with non-small cell lung cancer risk, ...
Mapping Cancer’s Fatty Footprints: Spatial Lipidomics Enters the Clinic’s Waiting Room
A new review maps how spatial lipidomics is reshaping the study of ovarian, endometrial, and cervical cancers while warning that ...
Common Sunscreen Chemical Benzophenone-1 Reprograms Immune Cells to Fuel Breast Cancer Growth in Lab Study
New research shows the UV filter benzophenone-1 shifts macrophages toward a tumor-supportive M2-like state, and the conditioned medium from these ...
Single-cell and bulk transcriptomic characterization of the osteosarcoma microenvironment reveals lineage-specific programs and inflammatory differences associated with metastasis
Osteosarcoma has long frustrated oncologists. It is the most common primary malignant bone tumor, striking hardest in adolescents, and while ...
Acrolein-Linked Gene Perturbation Tracks Tumor Immune Heterogeneity in Colorectal Cancer
A toxicogenomic reanalysis links acrolein-responsive gene dysregulation to immune-stromal heterogeneity in colorectal cancer, supported by single-cell localization and RT-qPCR validation ...
Three overlooked amino acid transporters emerge as promising anti-cancer targets
A new review highlights the System N amino acid transporters SLC38A3, SLC38A5 and SLC38A7 as emerging metabolic vulnerabilities in cancer, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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