RNA editing as an epitranscriptomic immune switch in tumor immunity and cancer immunotherapy
A review in Journal of Translational Medicine describes how dysregulated RNA editing suppresses tumor immune recognition and how programmable RNA ...
Tag: tumor microenvironment
Tumor protein stratifin blinds NK cells in bile duct cancer
A study in Journal of Translational Medicine shows that the tumor protein stratifin stabilizes PAK1 and activates MYC-driven NECTIN2 expression, ...
Multi-lineage reprogramming and NOTCH-associated signaling remodeling characterize the aggressive biology of early-onset colorectal cancer
A seven-cohort single-cell atlas links early-onset colorectal cancer to coordinated epithelial, stromal and NOTCH-associated signaling changes.
miR-142-3p suppresses tumors but can reshape their surroundings
A 2026 review finds that miR-142-3p generally suppresses tumor-cell growth and improves drug response inside cancer cells, while its extracellular-vesicle ...
CT Fat Density Reveals Region-Specific Changes Around Kidney Cancer
A retrospective CT study found localized differences in perirenal fat density around renal cell carcinoma, but the association was no ...
Disordered substrates promote tumor cell escape in simplified models
Laboratory experiments and simulations indicate that disordered substrates can roughen tumor-cell boundaries and promote detachment, a mechanism that remains to ...
Research report: Progress in the Mechanism of Heat Shock Proteins in Gastric Cancer: From Biomarkers to Therapeutic Targets
A narrative review links heat shock proteins to gastric cancer invasiveness, resistance and immune modulation, but finds that most therapeutic ...
Extracellular Vesicles Could Map the Location of Metastatic Cancer
A proposed liquid-biopsy strategy combines tumor-associated and organ-associated markers on circulating extracellular vesicles to infer metastatic sites, but it remains ...
TCR-engineered T cells advance toward harder liver cancer targets
A 2026 review finds that TCR-engineered T cells have entered early clinical testing for hepatocellular carcinoma, but safety, antigen heterogeneity ...
Small spatial-transcriptomics study links metabolism to T-cell exclusion in esophageal adenocarcinoma
A small clinical study linked lipid metabolism and mitochondrial respiration to low CD8-positive T-cell infiltration in esophageal adenocarcinoma using spatial ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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