When Lung Cancer Changes Identity: Study Maps the Immune Shift Behind Drug Resistance
A paired genomic and transcriptomic study of 32 patients shows that EGFR-mutant lung adenocarcinoma transforms into an immunosuppressed yet immunologically ...
Tag: tumor immune microenvironment
Chemical Tag on mRNA Emerges as Master Switch Behind Tumor Immune Evasion
A new review in the Journal of Translational Medicine details how the m6A RNA modification acts as a bidirectional switch ...
Hidden armies inside glioblastoma: exhausted T cells hint at new immunotherapy routes
Single-cell analysis of 56 glioblastoma tumors reveals that T-cell-rich cases harbor clonally expanded, LAG3-high CD8 T cells that may be ...
c-MET Signaling Reshapes the Lung Cancer Immune Landscape in Space and Metabolism
A new review in the Journal of Translational Medicine argues that c-MET signaling shapes spatially confined, metabolically driven immunosuppressive niches ...
How Tumor Mechanics Control Whether Mitochondrial DNA Fuels or Fights Cancer Immunity
A new review in the Journal of Translational Medicine proposes that the physical mechanics of solid tumors govern whether mitochondrial ...
Atypical B Cells Emerge as Key Players in Gastric Cancer Spread, Study Finds
A large computational study links TTN/TP53 co-mutations in gastric cancer to a prognostically favorable population of tumor-associated atypical B cells ...
Inside Tumors’ Hidden Immune Hubs: Spatial Maps Reveal Zoned Architecture of Tertiary Lymphoid Structures
A new spatial transcriptomics study shows that tertiary lymphoid structures in tumors are spatially zoned immune organs whose core-periphery organization ...
Liver Cancer Gene GNG4 Found to Build Walls That Keep Immune Cells Out of Tumors
New research links the gene GNG4 in malignant liver cells to tumor immune exclusion and reduced CD8-positive T cell infiltration ...
Miniature Brain Tumors in a Dish Offer New Hope for Beating Immunotherapy Resistance
A new review in the Journal of Translational Medicine describes how brain tumor organoid platforms are being used to reconstruct ...
Immune Cell Clusters Inside Brain Tumors Predict Glioblastoma Survival
A new grading system for tertiary lymphoid structures in glioblastoma tissue identifies patients with significantly longer survival and may guide ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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