Intravenous STING Agonist Supercharges Radiotherapy to Trigger Anti-Tumour Immunity
A novel intravenous STING agonist, BI 1703880, synergises with radiotherapy and checkpoint inhibitors to generate durable anti-tumour immunity in preclinical ...
Tag: tumor immune microenvironment
New Cancer Framework Ties Epigenetics, DNA Repair and Immunity Into One Immunogenicity Score
A new multi-omics framework proposes that tumor immunogenicity emerges only when epigenetic permissiveness, DNA damage response configuration and immune activation ...
Esophageal Cancer at a Crossroads: Landmark Review Maps Molecular Drivers and Next-Generation Therapies
A comprehensive Chinese Medical Journal review led by Professor Feng Wang synthesizes five years of advances in esophageal cancer, highlighting ...
A Fat-Burning Switch That Turns Immune Cells Into Cancer Killers
Cold Spring Harbor Laboratory researchers found that activating the transcription factor PPARD in immune cells, including CAR T cells, boosts ...
Sliced Tumors Keep Their Immune System Alive, Opening a New Window on Bladder Cancer Drug Testing
Researchers at Lund University have shown that precision-cut slices of bladder tumors keep their immune cells alive and functional for ...
Ribosome-Building Enzyme DIMT1 Emerges as a Pan-Cancer Biomarker and Gastric Cancer Drug Target
A comprehensive pan-cancer study identifies the ribosome biogenesis enzyme DIMT1 as a prognostic and immune-associated biomarker whose depletion suppresses gastric ...
Single-Cell Atlas Reveals DLL3 as a Drug Target in Aggressive Cervical Cancer
A single-cell multi-omic atlas of neuroendocrine carcinoma of the cervix identifies DLL3 as a driver of immune evasion and validates ...
Tumor Protein LRG1 Hijacks Neutrophil Mitochondria to Fuel Dangerous Vessel Growth in Bladder Cancer
New research in Advanced Science reveals that the secreted protein LRG1 drives pathological angiogenesis in bladder cancer by binding ANXA2 ...
Hidden Metabolic Trick Lets Myeloma Cells Steal Fuel to Survive a Key Cancer Drug
New research reveals that resistant myeloma cells import putrescine through the transporter SLC45A4, activating HOXA1-driven NF-kappaB signaling with help from ...
Macrophage Enzyme MMP14 Helps Tumors Build an Immune Shield, Study Finds
A new study shows that the macrophage enzyme MMP14 generates soluble semaphorin 4D, a signal that builds an immunosuppressive tumor ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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