AI Decodes the Hidden Grammar of the Genome’s Master Organizer CTCF
A new computational framework called DeCTCF uses AI-predicted epigenomic features to sort more than 236,000 CTCF binding sites into 20 ...
Tag: transcription factors
Symbiotic Bacteria Carry a Hidden Arsenal of Gene-Controlling Weapons, Structural Study Reveals
A structural analysis using AlphaFold2 reveals that symbiotic rhizobial effectors are modular proteins carrying hidden DNA- and RNA-binding domains, including ...
Master Gene Switches in the Brain Emerge as New Drug Targets for Psychiatric Disease
A new review in Translational Psychiatry identifies the TCF/LEF transcription factor family as central nuclear effectors of Wnt/β-catenin signaling and ...
Blood Cells From 80-Year-Olds Rejuvenated Into Brain Cells With Molecular Age Under 20
University of Bonn researchers directly reprogrammed red blood cell precursors from elderly donors into neural stem cells whose epigenetic clocks ...
One Obesity Gene Variant Rewires Nearly 100 Genes in Fat Cells, Study Finds
Researchers combined single nucleus RNA-sequencing with GWAS and UK Biobank data to show that an obesity-linked variant in SREBF1 allele-specifically ...
Wheat’s Hidden Salt-Stress Genes: Scientists Map the ARID Family From Root to Grain
A genome-wide study of wheat has identified twenty ARID transcription factor genes, showing that they evolved largely through segmental duplication ...
How a Plant Hormone Helps Tomatoes Beat the Heat: New Clues From the Photosynthesis Genes
New research shows that the plant hormone 2,4-epibrassinolide protects tomato photosynthesis under heat stress by preserving chloroplast structure and activating ...
Ancient Jumping Genes Help Explain How DNA Variants Shape the Human Cortex
A massively parallel reporter assay of 9,092 cortical-structure-associated variants reveals that Alu retrotransposons, Wnt signaling and transcription factor expression jointly ...
Black Sorghum Genome Cracked: New Reference Reveals Secrets of Rare Antioxidant-Rich Grain
Scientists have assembled the first reference genome of black pericarp sorghum Tx3362 and mapped the genes and transcription factors behind ...
Blood Cells Rewound: Direct Neural Conversion Slowly Erases Epigenetic Age
Direct conversion of human blood cells into neural stem cells erases nearly all epigenetic age over a protracted fifty-day process ...
-
Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
-
University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
-
Bee body mass, pathogens and local climate influence heat tolerance
-
Researchers record first-ever images and data of a shark experiencing a boat strike
-
Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!