Cancer Cells Turn Fat Factories: SOX9 Fuels Colorectal Cancer Spread Through Lipid Rewiring
New research reveals that the transcription factor SOX9 drives colorectal cancer metastasis by directly activating the fat-synthesizing enzyme FASN, and ...
Tag: transcription factors
How a Rare Medicinal Plant Builds Its Silkworm-Like Rings: Multi-Omics Study Reveals the Mechanism
A multi-omics study reveals that the prized silkworm-like rings of the medicinal plant Notopterygium incisum form through uneven secondary growth, ...
Gliding Mammals Evolved the Same Skill Through Different Genetic Routes
A genomic comparison of three independently evolved gliding mammal lineages shows that different regulatory DNA regions can converge on similar ...
Two Master Genes That Decide Whether Blood Cells Are Born or Turn Cancerous
A new review details how the Runx1 and Gata2 transcription factors architect the epigenetic landscape of blood formation and how ...
Hidden RNA Switches May Explain How Eucalyptus Leaves Turn Red Under Stress
A new full-length transcriptome study reveals extensive alternative splicing and identifies three MYB113 genes, including the unusual MYB113c, as regulators ...
How a Shifting Cast of Transcription Factors Rewires Androgen Signaling in the Aging Brain
New research shows that Alzheimer's disease disrupts androgen receptor signaling in the male brain by dismantling the collaborative transcription factor ...
Single Transcription Factor PU.1 Rapidly Converts Fibroblasts into Macrophage-Lineage Cells
Researchers at Mie University show that the transcription factor PU.1 alone can rapidly reprogram fibroblasts into transplantable macrophage-lineage cells, bypassing ...
New Topic Model Traces Cell Identity Back to Regulatory Paths in Single-Cell Data
Researchers have developed RegPathTopic, a deterministic topic-modeling framework that builds traceable regulatory vocabularies from transcription factor-target graphs and benchmarks them ...
Scientists Crack the Pomegranate Code: PgMYB10 Emerges as Master Switch for Red Pigment
Researchers have built the first efficient stable transformation system for pomegranate and used it to show that the transcription factor ...
Ancient Willow Relative Yields Secrets of a Master Gene Family That Builds Plants
A genome-wide study of the rare Korean willow has cataloged its 14 WUSCHEL-related homeobox genes, revealing conserved subgroups, tandem duplications, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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