Chemical Tags on RNA Take Center Stage in Cancer’s Growth and Immune Evasion
A new review in Molecular Cancer details how the abundant RNA mark m6A drives cancer growth, immune evasion and treatment ...
Tag: Targeted therapy
Rare ALK Fusion Lung Cancer Shows Durable Response to First-Line Lorlatinib
A newly reported case shows that first-line lorlatinib achieved durable systemic and intracranial disease control in a patient with the ...
ADAM8/17 Emerges as a Promising Drug Target in Intrahepatic Cholangiocarcinoma
A new study identifies the enzymes ADAM8 and ADAM17 as causally linked drivers of intrahepatic cholangiocarcinoma and demonstrates that a ...
Immune checkpoint VSIR fuels gastric cancer growth by amplifying AXL signaling
New research in iScience reveals that the immune checkpoint molecule VSIR drives gastric cancer progression by transcriptionally activating and post-translationally ...
Lung Cancer Study Retracted Over Animal Ethics Concerns
A lung cancer study on buparlisib and eukaryotic elongation factor-2 has been retracted after tumors in the animal experiments exceeded ...
Fructose Fuels Pancreatic Cancer: New Vulnerability Found in KRAS G12D Tumors
A new review highlights fructose metabolism as a druggable weakness in KRAS G12D pancreatic tumors and proposes sodium citrate as ...
Lab-Grown Tumor Organoids Illuminate How Cancers Evade, Tolerate, and Resist Treatment
A new review in Molecular Cancer positions patient-derived organoids as living systems for mapping how cancers tolerate, persist through, and ...
Drug Interactions and Side Effects Shape Safe Prescribing of Lung Cancer Pills
A comprehensive review maps how food, acid-reducing drugs and liver enzymes alter the exposure of thirty lung cancer targeted therapies, ...
Liposomal Paclitaxel With HER-2 Blockers Shows Strong Real-World Results in Advanced Breast Cancer
A real-world study of 526 patients found that paclitaxel liposome combined with anti-HER-2 targeted therapies delivered median overall survival of ...
Liquid Droplets Inside Cancer Cells Explain Why a Leukemia Drug Works So Slowly
A new Cell Research study shows that BCR-ABL1 forms liquid-like phase-separated condensates inside leukemic cells that physically slow tyrosine kinase ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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