Two Decades of Data Reveal How Small Molecule Drugs Reshaped Lung Cancer Treatment
A two-decade bibliometric analysis of nearly 5,000 studies maps how small molecule drug research transformed lung cancer therapy, revealing China's ...
Tag: Targeted therapy
Spinal Intradural Metastasis Emerges as a Late, Molecularly Distinct Stage of Cancer Spread
A Johns Hopkins study of 69 patients maps intradural spinal metastasis as a late stage of cancer spread, showing median ...
Silent Receptor Boost: Non-Signaling CARs Supercharge T-Cells Against Head and Neck Cancer
Researchers in Düsseldorf report that co-expressing a non-signaling EGFR-binding CAR alongside EGFRvIII-specific CAR T-cells enhances killing of head and neck ...
Real-World Data Show Zanubrutinib Delivers Strong Results in 410 Leukemia Patients
A nationwide cohort of 410 patients shows zanubrutinib delivers high progression-free survival in CLL/SLL, with dose reductions and switches between ...
Cancer Drug Trametinib Shrinks Oral Tumors in Dogs, Trial Shows
A Cornell clinical trial found that the oral MEK inhibitor trametinib shrank or stabilized oral squamous cell carcinoma tumors in ...
How Lung Cancers Shed Their Identity to Outsmart KRAS Drugs
A new mouse study shows that lung adenocarcinomas can evade KRAS inhibitors by reprogramming their cellular identity through transcription factors ...
Gene Network Rewiring Reveals Hidden Drug Response Clues in Colorectal Cancer Organoids
Researchers in Japan used organoid-line-specific regulatory network analysis on patient-derived colorectal cancer organoids to uncover drug-response-associated subnetworks that conventional biomarkers ...
Chronic Inflammation Emerges as a Central Driver of Ovarian Cancer Progression
A new review in the Journal of Ovarian Research details how chronic inflammatory signaling pathways drive ovarian cancer progression and ...
Oral Wnt-blocking pill plus lenvatinib shows promise in endometrial cancer after immunotherapy fails
A phase 1b/2 trial found that the oral CBP–β-catenin inhibitor E7386 combined with lenvatinib produced durable responses in advanced endometrial ...
Two Proteins Found on Nearly All Liver Cancer Cells Point to a Dual-Target CAR-T Strategy
A study of 140 liver tumor samples shows that Glypican-3 and AXL are co-expressed in nearly all hepatocellular carcinomas, supporting ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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