Resistant Melanoma Cells Recruit Immune Cells to Thwart Targeted Therapy
BRAF inhibitor-resistant melanoma cells release M-CSF and remodel the immune microenvironment, and blocking this signal improved drug efficacy in mouse ...
Tag: Targeted therapy
Real-world study reports promising first-line orelabrutinib outcomes in CLL/SLL
A retrospective single-center study of 75 treatment-naive CLL/SLL patients reports an 86.7% response rate with frontline orelabrutinib monotherapy and no ...
Heat Shock Proteins Shape Cancer Growth and Treatment Resistance
A review describes how heat shock proteins influence tumor survival, metastasis, immune escape, and the design of future targeted cancer ...
Airway epithelial cells emerge as central drivers of asthma inflammation and remodeling
A new review explains how barrier disruption, alarmin release and epithelial repair programs drive asthma pathology and may offer new ...
Cholangiocarcinoma: New Advances Expose Stubborn Gaps in a Deadly Bile Duct Cancer
A new review maps the advances in diagnosing and treating cholangiocarcinoma while highlighting persistent gaps in early detection, drug resistance ...
HAT1 Emerges as a Driver of Glioblastoma Growth and Drug Sensitivity
A multi-omics study identifies the epigenetic regulator HAT1 as upregulated in glioblastoma, where its inhibition slows tumor growth and boosts ...
Delayed targeted antibiotics linked to higher mortality in vancomycin-resistant E. faecium bloodstream infections
A retrospective cohort study in Taiwan found that delayed targeted therapy was associated with higher mortality in vancomycin-resistant E. faecium ...
Oral IDH1 Inhibitor Ivosidenib Holds Rare Liver Cancer at Bay for 35 Months in Case Report
A case report documents 35 months of oral ivosidenib therapy with partial remission and no adverse events in a man ...
Nurses Emerge as Key Players in Taming Targeted Cancer Therapy Side Effects
A scoping review of 14 studies finds that nurse-led education, continuity-of-care programs, and telehealth monitoring are the main strategies for ...
Three Synaptic Receptors Define Aggressiveness in Glioblastoma
Researchers identified a three-receptor signature involving HRH1, ADRA2B, and CHRM3 that defines glioblastoma aggressiveness and correlates with poor patient survival.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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