Antibody–Drug Conjugates Reshape Solid Tumor Therapy Amid Safety and Target Challenges
A new review in Holistic Integrative Oncology charts the rapid rise of antibody–drug conjugates in solid tumors while detailing the ...
Tag: Targeted therapy
Two Blood Signals Diverge Early and Refine Liver Cancer Therapy Response
For patients with hepatocellular carcinoma, the first weeks of treatment are a diagnostic gray zone. The tumor is too large ...
Persister cells hiding in minimal residual disease drive cancer relapse
A new review outlines how drug-tolerant persister cells hidden within minimal residual disease drive cancer relapse and how pathway inhibitors, ...
Eye Cancer’s Hidden Weakness: CRISPR Screens Expose p300 as a Lifeline for GNAQ-Mutant Tumors
CRISPR-based synthetic lethal screening has identified the acetyltransferases p300 and CBP as essential chromatin partners for YAP-driven transcription in GNAQ-mutant ...
Osimertinib Outcomes in EGFR-Mutated Lung Cancer Hinge on Five Prognostic Factors, Meta-Analysis Finds
A new meta-analysis of 4,070 patients identifies EGFR L858R, poor performance status, and brain metastases as high-certency predictors of poorer ...
CDK7 inhibitor samuraciclib shows promise against resistant breast cancer in randomized trial
A randomized controlled trial published in Nature Communications reports that the oral CDK7 inhibitor samuraciclib combined with fulvestrant improved clinical ...
Lung Cancer That Hid in the Uterus: Rare Metastasis Fooled Doctors
A 77-year-old woman's uterine tumor turned out to be metastatic lung adenocarcinoma, a case highlighting how immunohistochemistry and genomic sequencing ...
Three-Day Whole Genome Sequencing Transforms Childhood Cancer Diagnosis
A UK study shows rapid whole genome sequencing cuts pediatric cancer diagnosis time from six weeks to three days while ...
Ovarian Cancer Cells Outsmart CXCR4 Blockade at High Doses, Study Finds
New research shows that blocking the CXCL12/CXCR4 signaling axis in ovarian cancer cells produces a paradoxical biphasic response, with moderate ...
A Rare EBV-Negative NK/T-Cell Lymphoma in an Infant Challenges What Doctors Know
A fulminant, disseminated, EBV-negative extranodal NK/T-cell lymphoma in a previously healthy infant was diagnosed only after death, underscoring the rarity ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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