PI3K/AKT/mTOR Pathway Emerges as Central Target in Gastrointestinal Cancers
A comprehensive review finds that the PI3K/AKT/mTOR signaling axis drives progression and therapy resistance in gastrointestinal cancers, but clinical success ...
Tag: Targeted therapy
International Experts Set the Rules for Precision Testing in Bile Duct Cancer
An international expert consensus published in Clinical Cancer Bulletin establishes fifteen recommendations for molecular biomarker testing in intrahepatic cholangiocarcinoma, defining ...
Nebulized Designer Exosomes Deliver Pirfenidone Directly to Fibrotic Lungs
Researchers engineered anti-FAP-targeted exosomes loaded with pirfenidone and showed that nebulized delivery outperforms intravenous injection in treating pulmonary fibrosis in ...
Adding an Antibody to Venetoclax Deepens Responses in Hard-to-Treat Lymphoma
A French retrospective study of 46 patients with relapsed or refractory Waldenström macroglobulinemia found that venetoclax combined with an anti-CD20 ...
Hidden RNA Tags May Steer Lung Cancer Growth, Treatment Response, and Survival
A sweeping review reveals how the RNA modification N6-methyladenosine orchestrates lung cancer progression, drug resistance, immunotherapy response, and survival prediction.
Mushroom Compound Pachymic Acid Supercharges Lenvatinib Against Liver Cancer by Starving Tumors of Sugar
A new study shows that pachymic acid, a compound from the medicinal mushroom Poria cocos, synergizes with lenvatinib against hepatocellular ...
Cancer Patients Rate the Skin-Care Education They Receive, and Researchers Are Listening
A Yale research letter in the Archives of Dermatological Research examines how cancer patients judge the usefulness of educational content ...
After Nine Years of ALK Drugs, Lung Cancer Switches Gears—and a Second Mutation Saves the Day
A case report documents an ALK-rearranged lung cancer patient who acquired a druggable EGFR L858R mutation after nearly nine years ...
Folate-tipped nanoparticles offer a new route into stubborn brain tumors
A new review in Medical Oncology examines how folic acid-decorated nanoparticles could carry chemotherapy and imaging agents directly into glioblastoma ...
Three-minute mass spectrometry test maps brain tumor margins during surgery
Purdue and Mayo Clinic researchers showed that a three-minute syringe touch spray mass spectrometry method can distinguish glioma from healthy ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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