Cancer Drug in Clinical Trials May Work Through an Entirely Different Target Than Assumed
A new study finds the experimental cancer drug zavondemstat and the research compound QC6352 act mainly by blocking the enzyme ...
Tag: Targeted therapy
Adding Brain Radiotherapy to Targeted Drugs Extends Survival in Lung Cancer Patients with Brain Metastases
A multicenter real-world study of 465 patients found that adding brain radiotherapy to first-line third-generation EGFR inhibitors improved survival in ...
Lactate Tag on Histones Fuels Drug Resistance in Head and Neck Cancer
New research shows that CBP-driven histone H3K18 lactylation activates GLI2 transcription, promoting head and neck squamous cell carcinoma progression and ...
c-MET Signaling Reshapes the Lung Cancer Immune Landscape in Space and Metabolism
A new review in the Journal of Translational Medicine argues that c-MET signaling shapes spatially confined, metabolically driven immunosuppressive niches ...
New Wave of Targeted and Immune Therapies Reshapes Marginal Zone Lymphoma Care
A new review in Annals of Hematology details how molecular profiling and a growing arsenal of targeted and immune-based therapies ...
Molecular Imaging Meets Genomics to Reshape Thyroid Cancer Care
A new review in the Journal of Translational Medicine shows how combining molecular imaging, genomic profiling, and computational biology is ...
Lung Cancer Outsmarts KRAS Drugs Through Two Distinct Escape Routes
MIT researchers have found that lung adenocarcinomas can evade KRAS inhibitors either by amplifying the KRAS gene or by transforming ...
Mutational Map of Gallbladder Cancer Reveals New Paths to Precision Therapy
A new review maps the recurrent mutations and signaling crosstalk driving gallbladder cancer, identifying ERBB2 and KRAS as hub targets ...
Rare Aggressive Sarcoma Shows Surprising Sensitivity to Targeted Small Molecules in New Lab Study
A new laboratory study shows that desmoplastic small round cell tumor cells are highly vulnerable to histone deacetylase inhibitors, p53 ...
Who Needs Intensive Lung Cancer Therapy? New Algorithm Aims to Match EGFR-Mutant Patients to the Right First Treatment
A new review proposes a risk-adapted algorithm to help clinicians decide which patients with advanced EGFR-mutant lung cancer need intensive ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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