Why EGFR Drugs Fail in Glioblastoma: A STAT3 Escape Route Takes Center Stage
A new review argues that glioblastoma evades EGFR-targeted therapies through compensatory STAT3 activation, positioning the EGFR–STAT3 axis as an adaptive ...
Tag: Targeted therapy
Dry Eye Disease Rewired: How Inflammation Drives a Self-Amplifying Loop in the Eye
A new review argues that dry eye disease is sustained by a self-amplifying inflammatory circuit linking the corneal epithelium, immune ...
β-Catenin Inhibitors Show Potent Activity Against Double-Mutant Endometrial Cancer in Preclinical Study
A new preclinical study shows that the β-catenin/CBP inhibitor ICG-001 selectively kills endometrial cancer cells carrying both PIK3CA and CTNNB1 ...
Hidden Genetic Fault Lines Reshape Gastric Cancer Treatment Maps in Landmark Chinese Cohort
A 563-patient genomic study from Peking University reveals how KMT2C/D loss-of-function alterations define a hypermutated, MSI-high subgroup of gastric cancer ...
ATR Inhibitor Ceralasertib Paired With Olaparib Shows Promise in BRCA-Mutant Breast Cancer
A Phase 1 trial found that combining the ATR inhibitor ceralasertib with the PARP inhibitor olaparib was generally well tolerated ...
Right-Sizing HER2-Positive Breast Cancer Treatment: New Algorithms Reshape Care Across the Disease Continuum
A new Nature Reviews Clinical Oncology review charts how HER2-targeted therapies, led by trastuzumab deruxtecan, are driving a shift from ...
FDA Approval of Daraxonrasib Marks Turning Point in Pancreatic Cancer Care
Sylvester Comprehensive Cancer Center researchers report an FDA approval for a pancreatic cancer pill that nearly doubled survival, alongside new ...
Vascular Receptor TLR4 Emerges as a Master Switch Between Vascular Aging and Targeted Senotherapeutics
A new review in Aging Cell positions endothelial TLR4 as a context-dependent molecular rheostat controlling vascular senescence, arguing that precision ...
Oncologist Dennis Slamon Wins 2026 Albany Prize for Targeted Breast Cancer Breakthroughs
UCLA oncologist Dr. Dennis Slamon has received the 2026 Albany Prize for discoveries that identified HER2-positive breast cancer and produced ...
Metastatic Cancer Patients Living Years Longer: Dutch Registry Reveals a Fourfold Surge
A Dutch registry study finds the number of patients living long-term with de novo metastatic incurable cancer more than quadrupled ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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