Four Asia-Pacific Nations, Four Paths: Why Cancer Genomics Success Hinges on Health Systems, Not Sequencers
A landmark comparative review finds that Japan, South Korea, China, and Australia have all mastered the technology of cancer genomics, ...
Tag: Targeted therapy
Pan-RAS Inhibitor Daraxonrasib Delivers Landmark Survival Gains in Pancreatic Cancer
Two landmark New England Journal of Medicine studies show the pan-RAS inhibitor daraxonrasib nearly doubles survival in previously treated metastatic ...
Copper and Iron Cell Death Pathways Offer a New Two-Front Attack on Liver Cancer
A new review in Medical Oncology argues that simultaneously targeting copper-triggered cuproptosis and iron-dependent ferroptosis could open a powerful two-front ...
Plant Nanoparticles Deliver a Protein-Degrading Drug That Strikes Colorectal Cancer
Scientists have engineered a PROTAC molecule that destroys the RARα protein and delivered it via Polygonatum sibiricum exosome-like nanoparticles, markedly ...
Scientists Block a Survival Switch That Lets Melanoma Cells Spread
Australian researchers have shown that blocking the BRN2 transcription factor reverses anoikis resistance in melanoma cells and sensitizes them to ...
Endothelial Exosomes Emerge as Precision Tools for Cardiometabolic Disease
A new review in the Journal of Translational Medicine outlines how endothelial-derived exosomes and their molecular cargos could serve as ...
Self-Assembling Carriers Could Redefine How Drugs Reach Their Targets
A new review in the Journal of Advanced Research details how self-assembling delivery platforms built from peptides, polyelectrolytes and natural ...
ROS1 Fusion Subtype Shapes Survival in Advanced Lung Cancer, Real-World Data Show
A real-world study of 55 patients with advanced ROS1-rearranged non-small cell lung cancer shows that fusion subtype, PD-L1 expression and ...
RNA Profiling Splits Deadly Dog Spleen Cancer into Three Actionable Subtypes
Researchers at the University of São Paulo used a qPCR-based gene expression panel to divide canine splenic hemangiosarcoma into three ...
Rare Leukaemia Case Reveals Aggressive Blood Cancer Wearing Two Masks at Once
Haematologists report the first documented case of acute myeloid leukaemia-myelodysplasia related presenting as acute basophilic leukaemia at diagnosis, in a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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