Spatial Niches May Explain Why Brain Implants Lose Their Signal Over Time
A new analytical framework proposes that spatial niches — recurring local cellular and molecular neighborhoods around implanted microelectrodes — could ...
Tag: Spatial transcriptomics
Spatial Transcriptomics Maps the Cellular Battlefields of Fatal COVID-19 Lungs
A spatial transcriptomics study of fatal COVID-19 lungs reveals progressive loss of endothelial and immune cells, explosive peribronchial fibroblast expansion, ...
One Brain Map, Two Diseases: Alzheimer’s and Multiple Sclerosis Share a Genetic Signature of Shrinkage
A large trans-disease meta-analysis of more than 6,900 brain scans finds that Alzheimer's disease and multiple sclerosis share a common ...
New spatial sequencing method maps RNA turnover kinetics across the mouse brain
Spatial NT-seq combines metabolic RNA labeling with in situ chemical recoding to co-map newly synthesized and pre-existing RNAs, revealing the ...
How the Four-Eyed Fish Rebuilt Its Retina to See in Air and Water at Once
Researchers have shown that the four-eyed fish Anableps anableps evolved its aerial vision through developmental expansion of the ventral retina ...
Intranasal Herpes Virus Remodels Brain Immune Cells in a Region-Specific Pattern
A multiomic study in PLOS Pathogens shows that intranasal HSV-1 infection drives localized, interferon-dominated remodeling of microglia in discrete brainstem ...
Hidden Cell-to-Cell Messaging Networks Drive Triple-Negative Breast Cancer Resistance
A new review argues that triple-negative breast cancer's heterogeneity and therapy resistance emerge from spatially organized paracrine signaling networks between ...
New Algorithm Zooms Across Scales to Reveal Hidden Signals in Spatial Genomics
Researchers have developed SpatialZoomer, a spectral graph-based tool that automatically identifies the biologically meaningful scales in spatial transcriptomics data, revealing ...
New AI Model Decodes the Signals That Guide Immune Cells Into Tumors
Researchers at MD Anderson developed an AI tool called SPACER that decodes the spatial signals attracting or repelling immune cells ...
Lost Tumour Suppressor on Chromosome 6q Drives Deadly Childhood Brain Cancer and Reveals a Drug Target
New research shows that loss of the tumour suppressor LATS1 on chromosome 6q drives Hippo pathway dysregulation in ultra-high-risk PFA ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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