Fibroblast collagen signal drives gut scarring and cancer in inflammatory bowel disease
A single-nuclei study reveals how CXCL14+ fibroblasts and SPP1+ macrophages form a collagen IV-driven feedback loop that promotes fibrosis and ...
Tag: Spatial transcriptomics
Myeloid IL6/STAT3 Signaling Builds Immunosuppressive Niche That Fuels Colitis-Linked Cancer
Multi-omics study reveals how myeloid-derived IL6/JAK/STAT3 signaling creates a spatially organized immunosuppressive niche that drives colitis-associated carcinogenesis, offering a potential ...
Single-Cell Sequencing Reveals Why Diabetic Foot Ulcers Refuse to Heal
A new review details how single-cell RNA sequencing is exposing the cellular and molecular failures that keep diabetic foot ulcers ...
Enhanced Recovery Care Reshapes Immune Response After Bladder Cancer Surgery
A retrospective study of 126 bladder cancer patients suggests that ERAS-based perioperative nursing care is associated with gentler postoperative immune ...
Scientists Map the Cellular Ecosystem That Drives Liver Cancer Spread Through Blood Vessels
Single-cell RNA sequencing of hepatocellular carcinoma reveals that MRC1-positive macrophages, endothelial capillarization, and strengthened PTPRM signaling define the tumor ecosystem ...
How Persistent HPV Infection Drives Cervical Precancer: Molecular Pathways, Immune Evasion and Emerging Technologies
A new review in Cellular and Molecular Life Sciences maps the molecular pathways, immune microenvironment and AI-driven technologies that shape ...
Spatial Niches May Explain Why Brain Implants Lose Their Signal Over Time
A new analytical framework proposes that spatial niches — recurring local cellular and molecular neighborhoods around implanted microelectrodes — could ...
Spatial Transcriptomics Maps the Cellular Battlefields of Fatal COVID-19 Lungs
A spatial transcriptomics study of fatal COVID-19 lungs reveals progressive loss of endothelial and immune cells, explosive peribronchial fibroblast expansion, ...
One Brain Map, Two Diseases: Alzheimer’s and Multiple Sclerosis Share a Genetic Signature of Shrinkage
A large trans-disease meta-analysis of more than 6,900 brain scans finds that Alzheimer's disease and multiple sclerosis share a common ...
New spatial sequencing method maps RNA turnover kinetics across the mouse brain
Spatial NT-seq combines metabolic RNA labeling with in situ chemical recoding to co-map newly synthesized and pre-existing RNAs, revealing the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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