Tag: Spatial transcriptomics

A sequential regimen combining chemical carcinogens and a Western diet reliably produces advanced hepatocellular carcinoma in male and female mice ...

Integrated single-nucleus and spatial transcriptomics of 43 choroid plexus tumours reveal ten tumour metaprograms that cluster by methylation subtype and ...

Researchers report that stromal APOL4 marks a distinct cancer-associated fibroblast state whose loss confers carboplatin resistance in ovarian cancer co-cultures ...

A new review maps the biomarkers, transcriptomic signatures and methodological pitfalls involved in reliably identifying senescent vascular smooth muscle cells ...

A SCGB3A2-high tumor cell state in lung adenocarcinoma shows low angiogenesis and is associated with extracellular PGK2 and angiostatin signals.

Researchers have introduced CORAL, a probabilistic deep generative model that leverages graph attention to integrate multiscale spatial transcriptomic, proteomic, metabolomic, ...

A cross-species co-expression analysis of Pkd1-mutant mouse kidneys found circadian, sterol and mitochondrial modules deregulated weeks before cysts appeared.

Two studies show glioblastoma cells follow predictable paths between states, and reprogramming a single regulator improved survival in mouse models.

The ATLAS method imputes spatial single-cell maps of mouse brains and uncovers cell-type and regional composition differences between sexes and ...

A new Brain Informatics review traces how AI methods, from co-expression statistics to causal graph neural networks and foundation models, ...