Scientists Discover a Molecular Switch That Helps Breast Cancer Hide From Immunotherapy
New research shows that the stromal protein RAMP3 drives macrophage-mediated immune exclusion in breast cancer and undermines PD-1 blockade, suggesting ...
Tag: Spatial transcriptomics
Machine Learning Hunt Pinpoints Gene Linked to a Heart Drug’s Lung Damage
An integrated multiomics and machine learning study has identified SERPING1 as a leading candidate biomarker for amiodarone-induced pulmonary fibrosis, with ...
New AI Study Reveals What Actually Matters When Mapping Tissue Architecture
A new graph neural network study of spatial transcriptomics finds that attention mechanisms, not elaborate edge features, drive accurate identification ...
Scientists Map a Hidden Malignant Program in Triple-Negative Breast Cancer
An integrated single-cell and spatial transcriptomic study has identified a triple-negative breast cancer-enriched malignant epithelial program, EP5, linked to aggressive ...
Light-Patterned DNA Tags Give Single-Cell Sequencing a Sense of Place
A new light-based barcoding technique called scSTAMP-seq stamps spatial coordinates onto individual cells using photocleavable DNA tags, enabling joint transcriptomic ...
Spatial Hi-C Maps 3D Genome Folding Directly Inside Brain Tissue
A new microfluidic method called spatial Hi-C maps genome-wide 3D chromatin folding directly within intact brain tissue sections, revealing lobule-specific ...
NAD+ Collapse Drives Senescent CD8+ T Cells That Worsen Ulcerative Colitis
A new study in Aging Cell shows that NAD+ metabolic collapse drives senescent CD8+ T cells to fuel ulcerative colitis ...
Ancient Herbal Formulas May Hold the Key to Unlocking Immunotherapy for Hard-to-Treat Colorectal Cancer
A new review proposes that standardized Traditional Chinese Medicine formulas could re-engineer the gut microbiome, myeloid cells, and tumor cell ...
Threaded Microneedles Deliver mRNA and Drugs to Precise Skin Layers
A modular threaded microneedle system delivers a senescence-fighting hydrogel to the dermis and metabolism-restoring mRNA nanoparticles to subcutaneous fat, reversing ...
Dual-Branch AI Framework CrossBranch Sharpens Cell-Type Maps Across Omics Data
A new dual-branch deep learning framework called CrossBranch improves the estimation of cell-type composition from bulk, proteomic, and spatial omics ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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