NIH Backs Boston University Team Building Biomarkers to Catch Lung Cancer Earlier
A five-year, $3.4 million National Cancer Institute grant will help a Boston University-led consortium translate the Lung Pre-Cancer Atlas into ...
Tag: Spatial transcriptomics
Hidden Fibroblast State at the Pancreatic Tumor Frontier Predicts Poor Survival and Points to Existing Drugs
Integrating single-cell and spatial transcriptomics, researchers identified a novel invasive-frontier fibroblast state and the multicellular community it defines, which independently ...
Hidden Brain Cells Called Oligodendrocytes Emerge as Unexpected Drivers of Parkinson’s Disease
A spatial multi-omics study in Nature Communications identifies disease-associated oligodendrocytes whose interleukin 33–ST2 signaling influences alpha-synuclein burden and motor symptoms ...
New AI Framework Reads Gene Maps Like Images to Reveal Hidden Cell States
A new computational framework called STARIT converts the spatial positions of mRNA molecules inside cells into image tensors, allowing deep ...
The Fibroblast Problem: Why Liver Cancer Drugs So Often Fail
A new review identifies three fibroblast-driven mechanisms that make liver cancer cells resistant to kinase inhibitors and immunotherapy, while warning ...
Cholesterol’s Hidden Geography: How Tumor Neighborhoods Fuel Resistant Prostate Cancer
A paired spatial multi-omics study of prostate cancer reveals that rising cholesterol during therapy tracks with castration resistance, as import-dominant ...
Landmark heart atlas reveals two-phase collapse of the failing right ventricle
A multi-platform transcriptomic atlas of the human right ventricle reveals a two-phase progression to failure, with early erosion of protective ...
Machine Learning Pinpoints ANKIB1 as a New Alzheimer’s Biomarker in Brain Insulating Cells
An integrated analysis of single-cell, bulk and spatial transcriptomic data identifies oligodendrocyte palmitoylation as a key dimension of Alzheimer's disease ...
Scientists map the cellular blueprint that sculpts every human face
A new single-cell and spatial atlas of the developing human face identifies 56 cell states, hundreds of spatial patterning genes ...
Macrophage Signal WNT5A Drives Lung Cancer Scarring That Blocks Immunotherapy
A new study reveals how SPP1-positive macrophages secrete WNT5A to activate matrix-remodeling fibroblasts in lung adenocarcinoma, building a stiff tumor ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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