Epigenetic YAP1–TEAD–TET1 pathway drives liver cancer without driver mutations
A mouse study from Institute of Science Tokyo shows the YAP1–TEAD–TET1 epigenetic pathway can drive hepatocellular carcinoma without canonical driver ...
Tag: Spatial transcriptomics
Spatial gene map reveals compartment-specific reprogramming in inflamed fatty livers
A spatial transcriptomics study of 16 MASH patients and eight controls maps compartment-specific CYP450 suppression, immune activation, and disrupted cell-cell ...
Osteosarcoma rewires matrix signaling as disease progresses
A 2026 Review argues that osteosarcoma survival and lung spread depend on stage-specific rewiring of extracellular-matrix signaling rather than one ...
AI Maps Glioma Ecosystems and Exposes a Macrophage-Driven Vulnerability in Glioblastoma
An AI-driven single-cell and spatial multi-omics study defines three glioma ecosystem states and shows that a hypoxic myeloid-mesenchymal state independently ...
BRCA Mutations Shape Immune Landscapes in Ovarian Cancer, Spatial Study Finds
A multi-omics study combining genomics and spatial transcriptomics finds that BRCA-mutated high-grade serous ovarian cancers show stronger interferon and inflammatory ...
Segmentation choices reshape spatial transcriptomics results, benchmark finds
A Nature Methods benchmark of 11 segmentation methods across 15 spatial transcriptomics datasets shows that algorithm and platform choices substantially ...
OpenDVP links spatial images to proteomes in proof-of-concept human tissue studies
The openDVP framework combines microscopy, spatial analysis and proteomics in proof-of-concept human placenta, lung-cancer and relapsed breast-cancer studies.
Research report: A kinematic interpretation of spatial expression gradients from single-snapshot spatial transcriptomics
A computational framework linked spatial gene-expression gradients to net-production direction under steady-state and positive-flow assumptions, with reproducible directions in human ...
Immune and proliferative programs distinguish anti-PD-1-responsive endometrial cancer
An exploratory multi-omics analysis links regulatory T-cell and proliferation programs to anti-PD-1 response in endometrial cancer, but the treatment comparison ...
SubPoE benchmarked for uncertainty-aware spatial multi-omics clustering
A computational benchmarking study found that SubPoE delivered the strongest average spatial-domain clustering results across eight paired spatial multi-omics datasets ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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