New Sequencing Method Captures the Hidden Conversations Between Cells
A new method called CCI-seq captures large-scale cell–cell interaction networks in tissues while preserving full single-cell transcriptomes, revealing interaction-driven gene ...
Tag: Spatial transcriptomics
Hidden Immune Saboteurs: Scientists Map the Cells That Shield Colorectal Tumors
By combining spatial and single-cell transcriptomics, researchers have mapped previously unknown immunosuppressive niches in colorectal cancer, including SPP1-positive macrophage rings ...
First Multiomic Atlas Reveals How the Human Brain’s Protective Layers Build Their Immune Defenses
A paired single-nucleus RNA and chromatin atlas with spatial transcriptomics charts how the human meninges, their blood-brain barrier endothelium, yolk ...
Scientists map the developing human heart cell by cell and reveal how Down syndrome disrupts it
A multimodal atlas of the developing human heart reveals 21 tissue niches, shows fetal pacemaker cells recruiting their own nerve ...
AI Method Reads Tissue Fingerprints to Find Disease Hotspots Earlier
A new deep-learning method called VIMA converts tissue patches into numerical fingerprints and uses rigorous statistics to uncover disease-associated spatial ...
ResolVI cleans up noisy spatial transcriptomics data after segmentation goes wrong
A new probabilistic deep learning model called ResolVI corrects misassigned RNA molecules and batch effects in spatial transcriptomics data, sharpening ...
Human Meninges Cell Atlas Upends Century-Old View of Meningioma Origins
The first single-cell and spatial atlas of the developing human meninges shows that meningioma tumours transcriptionally resemble dura mater cells ...
Exploding immune cells may explain why prostate drug therapy fails in some men
A new study shows that 5-alpha-reductase inhibitor therapy can trigger macrophage pyroptosis, HMGB1–AGER-driven epithelial senescence and club-cell reprogramming in the ...
Diseased Kidneys Age Faster at the Cellular Level, Single-Cell Epigenome Atlas Reveals
A cross-species single-cell epigenome atlas shows that kidney disease accelerates epigenetic aging most dramatically in tubular epithelial cells, which lose ...
Massive single-cell atlas reveals how diverse gut infections reprogram the intestinal lining
A new single-cell atlas of more than 500,000 cells shows that viral, bacterial, fungal and parasitic infections each leave distinct ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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