HDAC isoform targeting offers a precision route to treating neurodegeneration
A new review argues that disease-specific HDAC isoforms, not broad-spectrum inhibition, should guide epigenetic drug development for neurodegenerative diseases.
Tag: SIRT1
Macrophage Mitochondria Powered by P2RY11 Drive Fin Regeneration in Zebrafish
A zebrafish study shows that the ATP receptor P2RY11 sustains macrophage mitochondrial function through the SIRT1–PGC-1α axis and is required ...
SIRT1 Loss Drives Tumor Growth Through NSUN2 Lactylation and Asparagine Production
A new study reports that SIRT1-mediated delactylation of NSUN2 suppresses m5C-dependent asparagine biosynthesis in hypopharyngeal squamous cell carcinoma, and that ...
Archived DNA from German uranium miners confirms gene variants that shape radon-linked lung cancer risk
A study of archived DNA from 526 former WISMUT uranium miners with lung cancer found that mining radon exposure significantly ...
Review links mitochondrial dysfunction to inter-organellar aging network
A 2026 mechanistic review links mitochondrial dysfunction with oxidative damage, altered NAD+-dependent signaling and disturbed communication among organelles during aging.
Blocking a Protein-Cleaving Enzyme Extends Lifespan and Health in Aging Mice
A small-molecule inhibitor of the asparagine-cleaving enzyme AEP was associated with longer survival, reduced frailty, better cognition, and improved metabolic ...
NAD+ Keeps Brain Cilia Long and Lysosomes Young, Mouse Study Finds
Deep inside the brain, a tiny antenna on each neuron may determine how gracefully the body ages. A new study ...
Needles at Three Acupoints Rewire a Hypothalamic Signaling Axis to Protect the Hypertensive Heart
A twelve-week acupuncture protocol in hypertensive rats lowered blood pressure, restored a neuroprotective deacetylase in the brain's sympathetic control center, ...
Electroacupuncture May Retune the Vagus Nerve to Calm Long COVID Inflammation
A new review proposes that electroacupuncture may ease long COVID by activating vagal cholinergic anti-inflammatory signaling and restoring mitochondrial metabolic ...
Desert Plant Compound Restores Sleep-Deprived Brains by Switching On a Key Antioxidant Pathway
A new rat study shows that glycosides from the desert plant Cistanche reverse sleep deprivation-induced cognitive decline by activating the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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