Threaded Microneedles Deliver mRNA and Drugs to Precise Skin Layers
A modular threaded microneedle system delivers a senescence-fighting hydrogel to the dermis and metabolism-restoring mRNA nanoparticles to subcutaneous fat, reversing ...
Tag: SIRT1
Common Plant Compound Shields Testes From Chemotherapy Damage in Rat Study
A new rat study shows that protocatechuic acid, a natural plant-derived phenolic compound, protects testicular tissue from cisplatin-induced oxidative damage ...
Hidden Protein Trio Helps Cancer Cells Survive Radiation, Study Finds
A newly identified TIMELESS-SIRT1-Ku70 complex promotes assembly of the Ku DNA repair heterodimer, giving cancer cells resistance to radiation and ...
Cellular Recycling Switch SIRT1-FOXO1 May Hold Key to Taming Brain Inflammation
New research shows that the SIRT1-FOXO1 signaling axis acts as a molecular brake on excessive mitophagy and glycolytic metabolism in ...
Two-Timing Nanomedicine Rewires Heart Metabolism After a Heart Attack
Researchers developed a staged-release nanomedicine that coordinates early NAD+ replenishment with prolonged mitochondrial regulation to limit damage and preserve heart ...
Chemotherapy’s Hidden Survivors: Lactylation Switch Reveals How Colorectal Cancer Cells Hide From Treatment
A new Molecular Cancer study reveals how UQCRC2 lactylation and SIRT1-driven mitophagy allow colorectal cancer cells to survive chemotherapy in ...
SIRT1 Silences Jumping Genes by Stabilizing Heterochromatin Complexes
Researchers report that SIRT1 suppresses L1 retrotransposon activity by recruiting and stabilizing the heterochromatin factors Lamin B1 and KAP1, an ...
Plant Compound Syringaresinol Fires Up Muscle Hormone Irisin to Fight Weight Gain
New research shows the plant lignan syringaresinol activates the skeletal muscle SIRT1–PGC-1α–FNDC5/irisin axis in cells and high-fat-diet-fed mice, reducing weight ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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