Rare tau gene variant reshapes brain cell transcriptomes in Alzheimer’s and PSP
Single-nucleus RNA sequencing of postmortem brains reveals that carriers of the rare MAPT A152T variant show distinct cell type-specific gene-expression ...
Tag: single-nucleus RNA sequencing
Fibril-selective nanantibody reduces amyloid injury signals in human brain models
A fibril-selective, Fc-free nanantibody bound Alzheimer’s-associated amyloid assemblies and reduced injury signals in human neurons and forebrain organoids, while remaining ...
Research report: A kinematic interpretation of spatial expression gradients from single-snapshot spatial transcriptomics
A computational framework linked spatial gene-expression gradients to net-production direction under steady-state and positive-flow assumptions, with reproducible directions in human ...
Public-data reanalysis identifies cell-cycle signal in sinonasal cancer
A public-data reanalysis identified broad tumor-normal gene-expression changes in sinonasal squamous cell carcinoma and nominated four preliminary candidate biomarkers supported ...
Hidden Heart Fibroblast State Found Across Human DCM Datasets
A reanalysis of two public single-nucleus RNA-sequencing cohorts identifies a MEOX1-positive, FAP-positive, relatively ACTA2-low fibroblast state that is reproducibly enriched ...
Male and Female Brain Clocks Run on Different Molecular Wiring
Single-nucleus RNA sequencing reveals that male and female mice share the same lateral hypothalamic cell types but differ in the ...
A single-nucleus transcriptomic atlas of human inner ear development
Researchers have built a single-nucleus transcriptomic atlas of the developing human inner ear, revealing that Hedgehog signaling repression is required ...
Intranasal Herpes Virus Remodels Brain Immune Cells in a Region-Specific Pattern
A multiomic study in PLOS Pathogens shows that intranasal HSV-1 infection drives localized, interferon-dominated remodeling of microglia in discrete brainstem ...
Alzheimer’s Risk Gene BIN1 Acts as a Brake on Brain Inflammation
New research shows that the Alzheimer's risk gene BIN1 acts as a brake on microglial inflammation, and its loss exaggerates ...
Hidden Brain Cells Called Oligodendrocytes Emerge as Unexpected Drivers of Parkinson’s Disease
A spatial multi-omics study in Nature Communications identifies disease-associated oligodendrocytes whose interleukin 33–ST2 signaling influences alpha-synuclein burden and motor symptoms ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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