One Obesity Gene Variant Rewires Nearly 100 Genes in Fat Cells, Study Finds
Researchers combined single nucleus RNA-sequencing with GWAS and UK Biobank data to show that an obesity-linked variant in SREBF1 allele-specifically ...
Tag: single-nucleus RNA sequencing
Landmark heart atlas reveals two-phase collapse of the failing right ventricle
A multi-platform transcriptomic atlas of the human right ventricle reveals a two-phase progression to failure, with early erosion of protective ...
Brain stimulation heals paralysis and pain by fixing mitochondria in a single set of neurons
New research reveals that high-frequency transcranial magnetic stimulation restores motor function and relieves neuropathic pain after spinal cord injury by ...
Massive single-nucleus atlas reveals how genetic risk for brain disease acts cell by cell
A single-nucleus atlas of 5.6 million brain cells from 1,384 donors maps cell-type-specific genetic regulation underlying Alzheimer's disease, schizophrenia and ...
Astrocyte Redox Switch Linked to Synapse Damage in Multiple Sclerosis
A new single-cell and animal study links SLC7A11-high astrocyte states to antioxidant failure and synaptic remodeling in multiple sclerosis, pointing ...
Anti-ageing drug combo clears senescent cells and reverses liver scarring in first randomized trial
A phase-2 randomized trial shows intermittent dasatinib plus quercetin significantly improved liver fibrosis and resolved MASH in nearly half of ...
Pain’s Hidden Geography: Single-Cell Maps Reveal How Nerve Injury Rewires the Body’s Sensory Hub
A comprehensive review reveals that single-cell sequencing of the dorsal root ganglion shows neuropathic pain is not one disease but ...
Nerve Fibers Invade the Aging Lens, Revealing How Cataracts Take Hold
A single-cell atlas of 554 human cataract capsules reveals that nerve-like fibers invade the aging lens through an NRG1-ERBB3 signaling ...
Single-Cell Map Reveals Why Some Cholinergic Neurons Age Faster Than Others
Single-nucleus RNA sequencing of the mouse brain reveals that basal forebrain cholinergic neurons undergo uniquely damaging stress-related transcriptional changes with ...
Dogs and Humans Share Genetic Drivers of Liver Cancer, First Multi-Omics Study Reveals
A first-of-its-kind multi-omics study shows that dogs and humans share key genetic drivers and conserved tumor microenvironment features in hepatocellular ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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