Tumor-Made Androgen Marks Breast Cancer Subtype and Survival Odds
Breast tumors with high intratumoral androstenedione show gene activity linked to lower proliferation, earlier stage and better survival, while low ...
Tag: single-nucleus RNA sequencing
Loss of CD47 Shifts Mouse Hippocampus Toward a Mild Stress-Like State
Single-nucleus RNA sequencing shows that Cd47 loss shifts the mouse hippocampal transcriptome toward a state resembling mild excitotoxic stress.
Hypothalamus Neurons Steer Post-Anesthesia Sleep Disruption Through Cannabinoid Signaling
A mouse study finds that glutamatergic and GABAergic neurons in the dorsomedial hypothalamus regulate post-anesthesia sleep disturbance through distinct CB1 ...
Tree Shrews Mirror Human Sperm Development Better Than Mice, Study Finds
Single-cell transcriptomic analysis shows tree shrew sperm development resembles human and macaque patterns more closely than the mouse does.
Src kinase emerges as a molecular player in early tau pathology in Alzheimer’s disease
A new study links upregulated Src kinase and the transcription factor NEUROD2 to early tau pathology in Alzheimer's disease, supported ...
Single-nucleus maps of human skeletal muscle expose cell-specific genetic control of metabolic traits
A population-scale single-nucleus study of 287 human skeletal muscle biopsies maps cell-type-specific eQTLs and caQTLs that colocalize with thousands of ...
Scientists pinpoint THBS1 as a driver of fat tissue scarring in obesity and diabetes
A single-nucleus atlas of human visceral fat identifies THBS1-expressing stem cells and adipocytes as drivers of fibro-inflammatory remodeling in obesity ...
Statin-Linked GGPP-Rho-YAP Pathway Identified in Cells Around Liver Tumors
UCLA researchers identified a GGPP-Rho-YAP signaling pathway in hepatic stellate cells around MASLD-related liver tumors that statins suppressed in laboratory ...
Scientists Discover PINNED, a Previously Unrecognized Tumor of the Pineal Gland
Researchers have identified a previously unrecognized pineal gland tumor type, provisionally named PINNED, defined by a unique DNA methylation signature ...
AI Maps Glioma Ecosystems and Exposes a Macrophage-Driven Vulnerability in Glioblastoma
An AI-driven single-cell and spatial multi-omics study defines three glioma ecosystem states and shows that a hypoxic myeloid-mesenchymal state independently ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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