Lysosome Gene Signature Offers New Prognostic Tool for Lung Cancer
Researchers have built a 13-gene lysosome-related signature that predicts survival, immune landscape, and drug responses in lung adenocarcinoma patients.
Tag: Single-Cell RNA Sequencing
Dogs’ Insulin-Secreting Tumors Reveal Two Hidden Cancer Cell Types in First-of-Its-Kind Study
The first single-cell RNA sequencing study of naturally occurring insulinoma in any species reveals two distinct insulin-expressing cancer cell populations, ...
Immune Receptor LAIR1 Slows Leukemia Cell Growth by Triggering Cell Cycle Arrest and Apoptosis
New research shows that the immune inhibitory receptor LAIR1 is downregulated in chronic lymphocytic leukemia, and that restoring its expression ...
Aging Muscle Fails Through Broken Cell-to-Cell Communication, Review Finds
A new review in Aging Cell argues that skeletal muscle aging is driven by the breakdown of multicellular communication networks ...
Missing Lung Protein Mimecan Emerges as Hidden Driver of COPD Emphysema
Researchers in Shanghai have discovered that loss of the fibroblast-derived protein mimecan drives emphysema in COPD by unleashing Wnt5a signaling ...
Frozen but Faithful: Single-Cell Study Shows Cryopreserved Insulinoma Cells Keep Their Transcriptomic Identity
A multispecies single-cell RNA sequencing study shows that insulinoma cell lines from dogs, humans, rats and mice retain their transcriptomic ...
Massive Single-Cell Map of Childhood Brain Tumor Reveals Immune Signal That Predicts Survival
A single-cell and spatial transcriptomic atlas of medulloblastoma maps developmental hierarchies and identifies the PPIA-BSG tumor-immune signaling axis as an ...
Single-Cell Map Traces How Prostate Tumors Evolve to Resist Hormone Therapy
A single-cell re-analysis of 44 prostate cancer samples reveals that androgen deprivation therapy transiently activates immune programs within tumor cells ...
Single-Cell Atlas Reveals Macrophages That May Drive Chronic Kidney Transplant Rejection
A single-cell multi-omic study of transplanted mouse kidneys identifies SPP1-positive macrophages and a CEBPβ-centered regulatory program as candidate drivers of ...
Single-Cell Atlas of Glioma Reveals Astrocyte Gene TTYH1 as a Hidden Tumor Suppressor
An integrated single-cell and spatial multi-omics study of glioma identifies the astrocyte-associated gene TTYH1 as a tumor suppressor that impedes ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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