Macrophage STAT3 signaling linked to ferroptosis-related heart injury in sepsis
A new study links macrophage STAT3 signaling to a paracrine inflammatory environment associated with ferroptosis-related cardiomyocyte injury in septic cardiomyopathy.
Tag: Single-Cell RNA Sequencing
Large Genetic Study Pinpoints Seven New DNA Loci and 23 Proteins Tied to Macular Degeneration
An integrative genomic and proteomic study identified seven new genetic loci and 23 genetically supported plasma proteins for age-related macular ...
T-cell markers DHX58 and CD62L track checkpoint inhibitor response in gastric cancer
Organoid and clinical single-cell data link a DHX58-positive, CD62L-positive stem-like T-cell state to immune checkpoint blockade responsiveness in gastric cancer.
Two Gene Biomarkers Linked to Sperm Production Failure in Infertility Study
An integrative analysis of human NOA transcriptomic data and a Utf1 conditional knockout mouse model identifies ACTRT2 and AKAP4 as ...
Immune Cell Genes Track Ferroptosis Signals in Kidney Cancer
A multi-cohort study finds that five genes upregulated in clear cell renal cell carcinoma mark the immune microenvironment rather than ...
Macrophages Talk to Tumor Cells Through SPP1-CD44 to Foster Chemotherapy Tolerance in Nasopharyngeal Carcinoma
A single-cell study of pretreatment nasopharyngeal carcinoma biopsies identifies an SPP1-CD44 macrophage-tumor communication axis linked to chemotherapy tolerance.
Carmn Keeps Exocrine Gland Stem Cells Primed for Wnt Signaling
A new EMBO Reports study shows that the lncRNA Carmn sustains basal stemness across mammary, salivary, and lacrimal glands by ...
AI Reads Bladder Cancer Slides and Pinpoints RTN3 Behind Chemotherapy Resistance
A multimodal AI model built from routine pathology slides predicts bladder cancer survival and led researchers to RTN3, which drives ...
Single-cell atlas maps how topical imiquimod reshapes the spleen in a lupus-like mouse model
A new single-cell RNA sequencing study maps how topical imiquimod remodels splenic immune cells in a lupus-like mouse model, revealing ...
Mathematicians Map the Hidden Geometry of Gene Expression Across Species
A Kyoto University team has developed Species-OT, a computational method that compares the geometric shapes formed by gene expression patterns ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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