Newly Discovered Trypsinogen Variants Drive Immune Responses in IgG4-Related Disease
Researchers identified novel PRSS1 trypsinogen variants in IgG4-related disease tissue and linked them to M2 macrophage-driven type 2 immune responses.
Tag: Single-Cell RNA Sequencing
Scientists Roll Human Stem Cells Back to an Eight-Cell Embryo-Like State
Researchers have published a detailed protocol for generating totipotent eight-cell embryo-like cells from human pluripotent stem cells without using embryos.
AI Maps a Hidden Neutrophil Niche in Lung Cancer and Flags a New Drug Target
A deep learning pipeline integrating single-cell and spatial transcriptomics has revealed an OSM-primed neutrophil niche that sustains aggressive mesenchymal tumor ...
New Computational Framework Tracks Cell Migration Across Space and Time
Researchers have developed a computational framework that integrates time-series single-cell RNA sequencing with spatial transcriptomics to reconstruct spatiotemporal cell-type redistribution ...
New single-cell framework reveals how gene networks orchestrate transcriptional bursts
A new statistical framework called BurstLink jointly infers gene regulatory interactions and transcriptional bursting kinetics across entire gene networks from ...
Single-cell maps reveal how enhancers regulate their target genes
Genomic dark matter has long been the paradox at the heart of human genetics. The vast majority of disease-associated DNA ...
Graph Transformer Puts Rare Cell States on the Map in Single-Cell Data
A new heterogeneous graph transformer called scFormer connects cells through their most specific genes rather than their most similar neighbors, ...
Single-cell RNA sequencing maps gonadal changes during sex reversal in orange-spotted grouper
A single-cell transcriptomic study of the orange-spotted grouper, Epinephelus coioides, is offering an unprecedented view of how a fish gonad ...
Fallopian Tube T Cells May Prevent Ovarian Cancer Through Immune Surveillance
A pioneering study published in Nature Communications has uncovered a sophisticated immune surveillance mechanism located within the fallopian tubes, potentially ...
Combining Single-Cell Multiomics Unlocks Precise Identification of Rare Cell Types and States
Understanding the intricate tapestry of human cellular diversity stands as one of the most formidable challenges propelling contemporary biomedical research. ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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