Single-cell map reveals lncRNA networks shaping cancer outcomes
A pan-cancer single-cell framework identifies 667 cell-specific long noncoding RNAs and thousands of functional pairs linked to tumor heterogeneity and ...
Tag: Single-Cell RNA Sequencing
When Do Gene Network Maps Hold Up? New Study Maps the Robustness Rules of Omics Inference
A systematic reusability study of the CORNETO framework reveals that multi-sample biological network inference operates in distinct robustness regimes governed ...
Silent Interferon Signals May Flag Ovarian Tumors That Shrug Off Chemotherapy
A cautious reanalysis of single-cell, TCGA, MRI, and cell-line data links muted type-I interferon signaling and altered cell-state programs to ...
Single-Cell Atlas Reveals How a Rare ANO5 Mutation Dismantles Muscle From Within
The first single-cell RNA sequencing study of an LGMD R12 patient reveals stalled muscle regeneration, metabolic collapse, and activated immune ...
New Benchmark REACH Exposes How Rare Cancer Cell Detection Methods Collapse Under Pressure
A new reproducible benchmark called REACH evaluates ten computational methods for detecting rare malignant cells in single-cell RNA sequencing data, ...
Scientists Map the Hidden Cellular Wiring That Drives Rheumatoid Arthritis Joint Destruction
A cross-species single-cell and spatial transcriptomics study reveals a conserved Notch/AP-1 to fibronectin and thrombospondin signaling axis operating in a ...
Computational Study Links Metabolic Enzyme NNMT to a Triple Shield That Lets Cancer Cell Clusters Survive in the Bloodstream
A new computational framework links the metabolic enzyme NNMT to coordinated platelet, neutrophil, and immune exhaustion programs in circulating tumor ...
Preeclampsia-Linked Protease Prostasin Found Essential for Embryonic Blood Cell Maturation
New research in mice shows that loss of the preeclampsia-associated protease prostasin disrupts fetal red blood cell development and vascular ...
Mitochondrial quality control genes CDC42 and RBBP7 emerge as key players in rheumatoid arthritis
A new study integrating bulk and single-cell RNA sequencing identifies two mitochondrial quality control-related genes with distinct immune and metabolic ...
Patient-derived stem cells and organoids open a new window on Moyamoya disease
A new review maps how patient-derived induced pluripotent stem cells and three-dimensional vascular and neurovascular organoids are transforming Moyamoya disease ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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